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TIMP4 molecular target information overview


  • Molecular name: TIMP4, TIMP metallopeptidase inhibitor 4
  • Gene family: Tissue inhibitor of metallopeptidases
  • Alias: tissue inhibitor of metalloproteinase 4


    • Overview of TIMP4 molecular targets


    In humans, tissue inhibitor of metalloproteinase 4 (TIMP-4) is a protein encoded by the TIMP4 gene in the tissue inhibitor of metalloproteinase family. This family has four members, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Among the four known members of the TIMP family, TIMP-4 has common features of all TIMPs and its own unique features. Unlike TIMP-2, TIMP-4 does not promote the activation of MMP-2 precursors through activated MMP-14 (MT1-MMP). TIMP-4 mRNA is expressed at high levels in the heart and at lower levels in the kidney, pancreas, colon, and testis. TIMP-4 is expressed in a variety of cancers, including breast cancer, cervical cancer, endometrial cancer, glioma, and choriocarcinoma.


    Human TIMP4 molecular target information


    Molecular name: TIMP4, TIMP metallopeptidase inhibitor 4


    Alias:

    • metalloproteinase inhibitor 4
    • TIMP-4
    • tissue inhibitor of metalloproteinase 4
    • tissue inhibitor of metalloproteinases 4

    Gene sequence:NCBI_Gene: 7079

    Protein sequence:UniProtKB: Q99727


    Human TIMP4 target molecular function (prediction)


    Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of proteolysis; response to cytokine; and response to hormone. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in sarcomere. (multiple); prostate carcinoma in situ; and renal cell carcinoma.


    Mouse Timp4 molecular target information


    Molecular name:Timp4, tissue inhibitor of metalloproteinase 4


    Alias:

    • TIMP-4


    Gene sequence:NCBI_Gene: 110595

    Protein sequence:


    Mouse Timp4 target molecular function (prediction)


    Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Acts upstream of or within Notch signaling pathway. Predicted to be located in sarcomere. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including brain ventricular layer; heart; ovary; skin; and ventral gray horn. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human TIMP4 (TIMP metallopeptidase inhibitor 4).


    Rat Timp4 molecular target information


    Molecular name: Timp4, TIMP metallopeptidase inhibitor 4

    Alias:

    • LOC680130
    • metalloproteinase inhibitor 4
    • similar to Metalloproteinase inhibitor 4 precursor (TIMP-4) (Tissue inhibitor of metalloproteinases-4)
    • TIMP-4
    • Timp4_mapped
    • tissue inhibitor of metalloproteinase 4
    • tissue inhibitor of metalloproteinase 4 (mapped)
    • tissue inhibitor of metalloproteinases 4

    Gene sequence:NCBI_Gene: 680130

    Protein sequence:UniProtKB: P81556


    Rat Timp4 target molecular function (prediction)


    Predicted to enable metalloendopeptidase inhibitor activity; protease binding activity; and zinc ion binding activity. Involved in several processes, including ovulation cycle; response to lipopolysaccharide; and response to peptide hormone. Located in extracellular space and sarcomere. Biomarker of abdominal aortic aneurysm; congestive heart failure; and renal hypertension. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human TIMP4 (TIMP metallopeptidase inhibitor 4).