FMR1_MOUSE P35922
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UniProt:P35922
Recommended name：Synaptic functional regulator FMR1
EC number：
Alternative names：(Fragile X mental retardation protein 1 homolog) (FMRP) (Protein FMR-1) (mFmr1p)
Cleaved into：
GeneID：
Gene names (primary )：Fmr1
Gene names (synonym )：Fmr-1
Gene names (ORF )：
Length：614
Mass：68989
Sequence：MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPERQIPFHDVRFPPPVGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKDTFHKIKLEVPEDLRQMCAKESAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLILRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEAENEKSVPQEEEIMPPSSLPSNNSRVGPNSSEEKKHLDTKENTHFSQPNSTKVQRVLVVSSIVAGGPQKPEPKAWQGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKGYVTDDGQGMGRGSRPYRNRGHGRRGPGYTSGTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRRGGGRGQGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTADGSLQSASSEGSRLRTGKDRNQKKEKPDSVDGLQPLVNGVP
Tissue specificity：Expressed in brain (PubMed:8033209). Strongly expressed in the neonatal hippocampus (PubMed:15475576). Expressed in the brainstem (PubMed:14613971). Expressed in the cerebellum (PubMed:19193898). Expressed in neurons of hippocampal area CA3 (PubMed:17548835, PubMed:19193898). Expressed in neurons of the olfactory bulb including the granule, mitral, tufted and juxtaglomerular cells (PubMed:19193898). Expressed in both mature and immature olfactory sensory neurons (OSNs) (PubMed:19193898). Expressed in neurons in all layers and in all regions of cerebral cortex (PubMed:19193898). Expressed in mature oligodendrocytes (OLGs) (PubMed:23891804). Expressed in spermatogonia (at protein level) (PubMed:16790844). Expressed predominantly in the brain (PubMed:16000371). Expressed in testis (PubMed:8033209). {ECO:0000269|PubMed:14613971, ECO:0000269|PubMed:15475576, ECO:0000269|PubMed:16000371, ECO:0000269|PubMed:16790844, ECO:0000269|PubMed:17548835, ECO:0000269|PubMed:19193898, ECO:0000269|PubMed:23891804, ECO:0000269|PubMed:8033209}.
Induction：Rapidly and transiently up-regulated in response to metabotropic glutamate receptor activation in a protein synthesis-dependent manner in neurons (at protein level). {ECO:0000269|PubMed:14614133, ECO:0000269|PubMed:16908410}.
Developmental stage：
Protein families：FMR1 family