SRBP1_MOUSE Q9WTN3
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UniProt:Q9WTN3
Recommended name：Sterol regulatory element-binding protein 1
EC number：
Alternative names：(SREBP-1) (Sterol regulatory element-binding transcription factor 1)
Cleaved into：Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)
GeneID：20787
Gene names (primary )：Srebf1
Gene names (synonym )：Srebp1
Gene names (ORF )：
Length：1134
Mass：120537
Sequence：MDELAFGEAALEQTLAEMCELDTAVLNDIEDMLQLINNQDSDFPGLFDAPYAGGETGDTGPSSPGANSPESFSSASLASSLEAFLGGPKVTPAPLSPPPSAPAALKMYPSVSPFSPGPGIKEEPVPLTILQPAAPQPSPGTLLPPSFPAPPVQLSPAPVLGYSSLPSGFSGTLPGNTQQPPSSLPLAPAPGVLPTPALHTQVQSLASQQPLPASAAPRTNTVTSQVQQVPVVLQPHFIKADSLLLTAVKTDAGATVKTAGISTLAPGTAVQAGPLQTLVSGGTILATVPLVVDTDKLPIHRLAAGSKALGSAQSRGEKRTAHNAIEKRYRSSINDKIVELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLTLRSAHKSKSLKDLVSACGSGGGTDVSMEGMKPEVVETLTPPPSDAGSPSQSSPLSFGSRASSSGGSDSEPDSPAFEDSQVKAQRLPSHSRGMLDRSRLALCVLAFLCLTCNPLASLFGWGILTPSDATGTHRSSGRSMLEAESRDGSNWTQWLLPPLVWLANGLLVLACLALLFVYGEPVTRPHSGPAVHFWRHRKQADLDLARGDFPQAAQQLWLALQALGRPLPTSNLDLACSLLWNLIRHLLQRLWVGRWLAGQAGGLLRDRGLRKDARASARDAAVVYHKLHQLHAMGKYTGGHLAASNLALSALNLAECAGDAISMATLAEIYVAAALRVKTSLPRALHFLTRFFLSSARQACLAQSGSVPLAMQWLCHPVGHRFFVDGDWAVHGAPPESLYSVAGNPVDPLAQVTRLFREHLLERALNCIAQPSPGAADGDREFSDALGYLQLLNSCSDAAGAPACSFSVSSSMAATTGPDPVAKWWASLTAVVIHWLRRDEEAAERLYPLVEHIPQVLQDTERPLPRAALYSFKAARALLDHRKVESSPASLAICEKASGYLRDSLASTPTGSSIDKAMQLLLCDLLLVARTSLWQRQQSPASVQVAHGTSNGPQASALELRGFQHDLSSLRRLAQSFRPAMRRVFLHEATARLMAGASPARTHQLLDRSLRRRAGSSGKGGTTAELEPRPTWREHTEALLLASCYLPPAFLSAPGQRMSMLAEAARTVEKLGDHRLLLDCQQMLLRLGGGTTVTSS
Tissue specificity：[Isoform SREBP-1C]: Predominant isoform expressed in most tissues (PubMed:21531336). Predominates in liver, adrenal gland, brain and adipose tissue (PubMed:9062340). Also found in kidney, thymus, testis, muscle, jejunum, and ileum (PubMed:9062340). {ECO:0000269|PubMed:21531336, ECO:0000269|PubMed:9062340}.; [Isoform SREBP-1A]: Expressed only in select tissues, such as intestinal epithelial, heart, macrophage and bone marrow dendritic cells (PubMed:9062340, PubMed:21531336). Also found in kidney, thymus, testis, muscle, jejunum, and ileum (PubMed:9062340). {ECO:0000269|PubMed:21531336, ECO:0000269|PubMed:9062340}.
Induction：[Isoform SREBP-1C]: Expressed in a circadian manner in the liver with a peak at ZT16 (PubMed:19786558). {ECO:0000269|PubMed:19786558}.; Up-regulated by endocannabinoid anandamide/AEA. {ECO:0000269|PubMed:21987372}.
Developmental stage：
Protein families：SREBP family