DUS4_RAT Q62767
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UniProt:Q62767
Recommended name:Dual specificity protein phosphatase 4
EC number:EC:3.1.3.16
Alternative names:Mitogen-activated protein kinase phosphatase 2 (MAP kinase phosphatase 2; MKP-2)
Cleaved into:
GeneID:60587
Gene names (primary ):Dusp4
Gene names (synonym ):Mkp2
Gene names (ORF ):
Length:395
Mass:43,187
Sequence:MVTMEELREMDCSVLKRLMNRDENGGTAGSSGGSHGALGLLSGGKCLLLDCRPFLAHSAGYIRGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSTNESLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLTTSCAAEAASPSGPLRERGKATPTPTSQFVFSFPVSVGVHAAPSNLPYLHSPITTSPSC
Tissue specificity:Expressed at moderate levels in nearly all tissues and cells including brain, spleen, and testes with the higher expression in the heart and lung and lower expression in skeletal muscle and kidney. Undetectable in liver. Expressed in many areas of the brain with very strong expression in the hippocampus, piriform cortex, and the suprachiasmatic nucleus.
Induction:
Developmental stage:By mitogens and by stress.
Protein families: