VEGFA molecular target information overview
Overview of VEGFA molecular targets
Vascular endothelial growth factor (VEGF) is a subfamily of growth factors, specifically, the platelet-derived growth factor (PDGF) family of cystine knot growth factors. They are important signal transduction proteins involved in vasculogenesis (formation of the embryonic circulatory system from scratch) and angiogenesis (growth of blood vessels from pre-existing vasculature). VEGF can stimulate both vasculogenesis and angiogenesis. When blood circulation is insufficient, it can participate in restoring the oxygen supply to tissues. The most important role of VEGF is angiogenesis. During embryogenesis, VEGF regulates the proliferation, migration and survival of endothelial cells, thereby regulating the density and size of blood vessels, but it cannot determine the type of blood vessels. VEGF is found in high concentrations in the serum of patients with bronchial asthma and diabetes. When VEGF is overexpressed, it can cause disease. When blood supply is insufficient, the size of solid tumors is limited; tumors that express VEGF continue to grow and metastasize. Overexpression of VEGF can lead to vascular diseases in the retina of the eye and other parts of the body. Bevacizumab and ranibizumab can inhibit VEGF and control or slow the progression of the disease.
Human VEGFA molecular target information
Molecular name:VEGFA, vascular endothelial growth factor A
Alias:
- MGC70609
- MVCD1
- vascular endothelial growth factor
- vascular endothelial growth factor A121
- vascular endothelial growth factor A165
- vascular permeability factor
- VEGF
- VEGF-A
- VPF
Gene sequence:NCBI_Gene: 7422
Protein sequence:UniProtKB: P15692
Human VEGFA target molecular function (prediction)
Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; positive regulation of endothelial cell proliferation; and regulation of nitric oxide mediated signal transduction. Located in several cellular components, including adherens junction; cell surface; and secretory granule. Implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); inflammatory bowel disease (multiple);
Mouse Vegfa molecular target information
Molecular name:Vegfa, vascular endothelial growth factor A
Alias:
- vascular endothelial growth factor
- Vegf
- VEGF-A
- VEGF120
- VEGF164
- VEGF188
- VPF
Gene sequence:NCBI_Gene: 22339
Protein sequence:
- UniprotKB: Q00731
- UniprotKB: A0FKR4
- UniprotKB: E9Q4N8
- UniprotKB: E9Q4N9
- UniprotKB: F8T7H0
- UniprotKB: F8WH10
- UniprotKB: F8WH81
- UniprotKB: Q5UD54
- UniprotKB: Q6YLN3
Mouse Vegfa target molecular function (prediction)
Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and vasculature development. Located in cytoplasm; extracellular space; and nucleus. Is expressed in several structures, including alimentary system; brain; egg cylinder; genitourinary system; and heart. Used to study DiGeorge syndrome; amyotrophic lateral sclerosis type 1; newborn respiratory distress syndrome; and psoriasis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A).
Rat Vegfa molecular target information
Molecular name:Vegfa, vascular endothelial growth factor A
Alias:
- vascular endothelial growth factor
- vascular permeability factor
- Vegf
- VEGF-A
- VEGF111
- VEGF164
- VPF
Gene sequence:NCBI_Gene: 83785
Protein sequence:
- UniprotKB: A0A0G2K6Z7
- UniprotKB: A0A0H2UHY5
- UniprotKB: B5DEK7
- UniprotKB: F1M6X1
- UniprotKB: F8WG85
- UniprotKB: G8JLS5
- UniprotKB: P16612
- UniprotKB: Q541S7
- UniprotKB: Q91ZE2
Rat Vegfa target molecular function (prediction)
Enables several functions, including identical protein binding activity; receptor ligand activity; and vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including negative regulation of cell death; response to steroid hormone; and response to vitamin. Located in basement membrane; extracellular space; and vesicle. Used to study several diseases, including brain edema; limb ischemia; middle cerebral artery infarction; ovarian hyperstimulation syndrome; and proliferative diabetic retinopathy. Biomarker of several diseases, including adheions of uterus; attention deficit hyperactivity disorder; brain edema; liver disease (multiple); and retinal vascular disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); hypertension (multiple); endothelial growth factor A).