Interferons(IFNs)
The interferon (IFN) family comprises three classes: type I (IFN-α/β/κ/ε/ω), type II (IFN-γ) and type III (IFN-λ1/2/3). Type I IFNs are rapidly produced upon viral or nucleic-acid sensing and signal through IFNAR1/2 to activate JAK-STAT1/2, inducing hundreds of interferon-stimulated genes (ISGs) that establish an antiviral state. Type II IFN, secreted by NK and Th1 cells, engages IFNGR1/2 to enhance macrophage activation and antigen presentation. Type III IFNs act locally at mucosal surfaces via IFNLR1/IL-10R2, also using STAT1/2. Beyond antiviral defense, IFNs modulate cell proliferation, apoptosis and tumor immune surveillance; dysregulation underlies chronic infection, autoimmunity and cancer immune evasion, making them central targets for IFN-based therapies and immune checkpoint strategies.
Product List
| Target | Catalog# | Product Name | Reactivity | Predicted MW |
|---|---|---|---|---|
| Limitin (C-6His) | PHM0970 | Recombinant Mouse Limitin (C-6His) | Mouse | 19.5 kDa |
| IFN gamma (C-6His) | PHM0969 | Recombinant Mouse IFN gamma (C-6His) | Mouse | 16.6 KDa |
| IFN gamma | PHM0968 | Recombinant Mouse IFN gamma | Mouse | 15.5 KDa |
| IL-29 (C-10His) | PHH1854 | Recombinant Human IL-29 (C-10His) | Human | 21.4 KDa |
| IL-28B | PHH1003 | Recombinant Human IL-28B | Human | 19.6 KDa |
IL-28A (C-6His) | PHH0965 | Recombinant Human IL-28A (C-6His) | Human | 20.6 kDa |
IFNW1 (C-6His) | PHH0835 | Recombinant Human IFNW1 (C-6His) | Human | 21.1 kDa |
| IL-28B (C-6His) | PHH0834 | Recombinant Human IL-28B (C-6His) | Human | 20.67 kDa |
| IFN gamma | PHH0833 | Recombinant Human IFN gamma | Human | 16.8 kDa |
| IFN alpha6 (C-6His) | PHH0827 | Recombinant Human IFN alpha6 (C-6His) | Human | 21.1 kDa |
| IFN alpha4 (C-6His) | PHH0826 | Recombinant Human IFN alpha4 (C-6His) | Human | 21.1 kDa |
| IFN alpha1 (C-6His) | PHH0823 | Recombinant Human IFN alpha1 (C-6His) | Human | 20.4 kDa |
| IFN alpha2 | PEM0967 | Recombinant Mouse IFN alpha2 | Mouse | 19.5 kDa |
| IFN gamma (E. coli) | PEM0832 | Recombinant Mouse IFN gamma (E. coli) | Mouse | 15.7 kDa |
| IFN gamma (E. coli) | PEH0831 | Recombinant Human IFN gamma (E. coli) | Human | 16.88 kDa |
| IFN alpha2b | PEH0825 | Recombinant Human IFN alpha2b | Human | 19.4 kDa |
| IFN alpha2a | PEH0824 | Recombinant Human IFN alpha2a | Human | 19.24 kDa |
Validation Data
Recombinant Mouse Limitin (C-6His) (Catalog: PHM0970） Recombinant Human IL-29 (C-10His) (Catalog: PHH1854)
Recombinant Human IFN alpha2a (Catalog: PEH0824) Recombinant Mouse IFN gamma (E. coli) (Catalog: PEM0832)
Related Products
Super-sensitive ECL chemiluminescent reagent
References
1. Type I IFN family members: similarity, differences and interaction. Capobianchi MR, et al. Cytokine Growth Factor Rev. 2015. [PMID: 25466633]
2. Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion. Broggi A, et al. J Exp Med. 2020. [PMID: 31821443]
3. The Role of Structure in the Biology of Interferon Signaling. Walter MR. Front Immunol. 2020. [PMID: 33281831]