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CFD Molecular Target Information Overview


  • Molecular name: CFD, complement factor D
  • Gene family: Granule associated serine proteases of immune defence; Complement system activation components
  • Alias: ADN
  • Previous name: DF; PFD
  • Alias: adipsin; D component of complement (adipsin); properdin factor D; complement factor D (adipsin)


    • CFD Molecular Targets Overview


    Complement factor D, or factor D, also known as lipase, is a serine protease that is required for activation of the alternative complement pathway. Factor D is a member of the trypsin family of peptidases and is encoded in humans by the CFD gene. Factor D is expressed in a variety of tissues, including monocytes/macrophages, muscle, sciatic nerve, endometrium, kidney, intestine, and especially at high levels in adipocytes. In patients with renal failure, circulating factor D concentrations are elevated. Similarly, in patients with Fanconi syndrome, the proximal tubules of the kidney are impaired and urinary factor D concentrations are also at high levels.


    Human CFD Molecular Target Information


    Molecular name: CFD, complement factor D


    Alias:

    • ADIPSIN
    • ADN
    • C3 convertase activator
    • complement factor D (adipsin)
    • complement factor D preproprotein
    • D component of complement (adipsin)
    • DF
    • PFD
    • properdin factor D

    Gene sequence:NCBI_Gene: 1675

    Protein sequence: UniProtKB: P00746


    Human CFD target molecular function (prediction)


    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in complement activation. Predicted to act upstream of or within several processes, including complement activation, alternative pathway; retina development in camera-type eye; and vascular associated smooth muscle cell differentiation. Located in extracellular exosome. Biomarker of obesity.


    Mouse Cfd molecular target information


    Molecular name: Cfd, complement factor D (adipsin)


    Alias:

    • adipsin
    • Adn
    • D component (adipsin) of complement
    • DF
    • factor D


    Gene sequence:NCBI_Gene: 11537

    Protein sequence:


    Mouse Cfd target molecular function (prediction)


    Predicted to enable endopeptidase activity. Acts upstream of or within several processes, including complement activation, alternative pathway; retina development in camera-type eye; and vascular associated smooth muscle cell differentiation. Located in extracellular space. Is expressed in adipose tissue; brown fat; epididymal fat pad; and white fat. Orthologous to human CFD (complement factor D).


    Rat Cfd molecular target information


    Molecular name: Cfd, complement factor D

    Alias:

    • adipsin
    • Adn
    • C3 convertase activator
    • complement factor D (adipsin)
    • D component of complement (adipsin)
    • Df
    • endogenous vascular elastase
    • EVE
    • properdin factor D

    Gene sequence:NCBI_Gene: 54249

    Protein sequence:


    Rat Cfd target molecular function (prediction)


    Enables endopeptidase activity. Involved in Notch signaling pathway. Located in extracellular space. Used to study arthus reaction. Biomarker of obesity. Orthologous to human CFD (complement factor D).