IFM3_MOUSE Q9CQW9
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UniProt:Q9CQW9
Recommended name：Interferon-induced transmembrane protein 3
EC number：
Alternative names：(Dispanin subfamily A member 2b) (DSPA2b) (Fragilis protein) (Interferon-inducible protein 15) (Mouse ifitm-like protein 1) (Mil-1)
Cleaved into：
GeneID：66141
Gene names (primary )：Ifitm3
Gene names (synonym )：
Gene names (ORF )：
Length：137
Mass：14954
Sequence：MNHTSQAFITAASGGQPPNYERIKEEYEVAEMGAPHGSASVRTTVINMPREVSVPDHVVWSLFNTLFMNFCCLGFIAYAYSVKSRDRKMVGDVTGAQAYASTAKCLNISTLVLSILMVVITIVSVIIIVLNAQNLHT
Tissue specificity：Expressed in acinar cell. Predominantly expressed in nascent primordial germ cells, as well as in gonadal germ cells. {ECO:0000269|PubMed:12659663, ECO:0000269|PubMed:15184081}.
Induction：By alpha interferon. Induced in pancreas during caerulein-induced pancreatitis. Induced in pancreas under systemic-lipopolysaccharide treatment and in intestine under Salmonella infection. {ECO:0000269|PubMed:15184081}.
Developmental stage：At 7.25 dpc strong expression is found at the base of the incipient allantois and weak expression in the mesodermal portion of the posterior amnion, and, importantly, the expression did not extend to the allantois. Expression persisted until the late bud stage (7.5 dpc), but gradually faded around the early head fold stage (7.75 dpc). At an earlier stage, only weak expression is seen throughout the epiblast in 6.0 dpc. But around 6.25-6.5 dpc (before gastrulation), marked expression is evident within the most proximal layer of the epiblast that is in intimate contact with the extraembryonic ectoderm. Expression is indeed induced by extraembryonic ectoderm through signaling molecules. During germ cell formation, is expressed in putative PGC ancestors in embryos at 6.5-7.5 dpc. In migrating PGCs, expression is continuous. After the beginning of gastrulation, the expression migrates to the posterior end of the developing primitive streak at the early/mid streak stage and became very intense in the position where PGCs (Primordial germ cells) differentiate from late streak stage onward. {ECO:0000269|PubMed:12124616, ECO:0000269|PubMed:14516695, ECO:0000269|PubMed:16326387}.
Protein families：CD225/Dispanin family