MK10_MOUSE Q61831
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UniProt:Q61831
Recommended name：Mitogen-activated protein kinase 10
EC number：EC 2.7.11.24
Alternative names：(MAP kinase 10) (MAPK 10) (MAP kinase p49 3F12) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
Cleaved into：
GeneID：26414
Gene names (primary )：Mapk10
Gene names (synonym )：Jnk3 Prkm10 Serk2
Gene names (ORF )：
Length：464
Mass：52532
Sequence：MSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSSIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRSYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPVKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKSQPSPSGAAVNSSESLPPSSAVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
Tissue specificity：Brain (at protein level). Expressed specifically in neurons of the hippocampus, cortex, cerebellum, brainstem, and spinal cord. Seems to be also found in testis, and very weakly in the heart. {ECO:0000269|PubMed:22441692}.
Induction：
Developmental stage：Expression begins in day 11.5 dpc embryos, and is localized in both the rostral spinal cord and rhombencephalon. In 12.5-13 dpc embryos, it is found throughout the telencephalon. By day 17.5, JNK3 is also expressed in neurons of dorsal root and sensory ganglia and at lower levels in neurons of the myenteric plexus and the developing heart.
Protein families：Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily