Blog

IGFBP4 molecular target information overview


  • Molecular name:IGFBP4, insulin like growth factor binding protein 4
  • Gene family:Insulin like growth factor binding proteins
  • Alias:IBP4; BP-4; HT29-IGFBP; IGFBP-4
  • Alias:IGF-binding protein 4; insulin-like growth factor-binding protein 4; insulin-like growth factor binding protein 4


    • Review of IGFBP4 molecular targets


    Insulin-like growth factor binding protein 4 (IGFBP4) is a 24 kDa protein that binds insulin-like growth factors (IGFs) I and II and circulates in plasma in glycosylated and non-glycosylated forms. This binding prolongs the half-life of IGFs and alters their interaction with cell surface receptors. The IGF-binding protein superfamily includes six high-affinity IGF binding proteins (IGFBPs), as well as at least four lower-affinity binding proteins called IGFBP-related proteins (IGFBP-RPs). IGFBP-4 inhibits the action of IGF-I in vitro and is the most abundant IGF binding protein in the rodent arterial wall. In non-transgenic littermates, IGFBP4 mRNA expression is highest in the liver and kidney.


    Human IGFBP4 Molecular Target Information


    Molecular name:IGFBP4, insulin like growth factor binding protein 4


    Alias:

    • BP-4
    • HT29-IGFBP
    • IBP-4
    • IBP4
    • IGF-binding protein 4
    • IGFBP-4
    • insulin-like growth factor binding protein 4
    • insulin-like growth factor-binding protein 4

    Gene sequence:NCBI_Gene: 3487

    Protein sequence:UniProtKB: P22692


    Human IGFBP4 target molecular function (prediction)


    Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Predicted to act upstream of or within several processes, including positive of signal transduction; regulation of glucose metabolic process; and type B pancreatic cell proliferation. Predicted to be located in endoplasmic reticulum lumen and extracellular region. Predicted to be active in extracellular space.


    Mouse Igfbp4 molecular target information


    Molecular name:Igfbp4, insulin-like growth factor binding protein 4


    Alias:

    • AI875747
    • Band 3A
    • Deb2
    • differentially expressed in B16F10 2
    • expressed sequence AI875747
    • IGFBP-4


    Gene sequence:NCBI_Gene: 16010

    Protein sequence:


    Mouse Igfbp4 target molecular function (prediction)


    Enables insulin-like growth factor binding activity. Acts upstream of or within several processes, including positive regulation of signal transduction; regulation of glucose metabolic process; and type B pancreatic cell proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; early embryo; female reproductive system; limb; and lung. Orthologous to human IGFBP4 (insulin like growth factor binding protein 4).


    Rat Igfbp4 molecular target information


    Molecular name:Igfbp4, insulin-like growth factor binding protein 4

    Alias:

    • IBP-4
    • IBP4
    • IGF-binding protein 4
    • IGF-BP4
    • IGFBP-4
    • insulin-like growth factor-binding protein 4

    Gene sequence:NCBI_Gene: 360622

    Protein sequence:UniProtKB: P21744


    Rat Igfbp4 target molecular function (prediction)


    Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in inflammatory response. Predicted to be active in extracellular space. Orthologous to human IGFBP4 (insulin like growth factor binding protein 4).