HS2ST_MOUSE Q8R3H7
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UniProt:Q8R3H7
Recommended name：Heparan sulfate 2-O-sulfotransferase 1
EC number：EC 2.8.2.-
Alternative names：(2-O-sulfotransferase) (2-OST) (2OST) (EC 2.8.2.-)
Cleaved into：
GeneID：23908
Gene names (primary )：Hs2st1
Gene names (synonym )：Hs2st
Gene names (ORF )：
Length：356
Mass：41813
Sequence：MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRAKLERAIARHEVREIEQRHTMDGPRQDATLDEEEDIIIIYNRVPKTASTSFTNIAYDLCAKNRYHVLHINTTKNNPVMSLQDQVRFVKNITTWNEMKPGFYHGHISYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKSNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATDLYRTGKKSHLRKTTEKKLPTKQTIAKLQQSDIWKMENEFYEFALEQFQFIRAHAVREKDGDLYILAQNFFYEKIYPKSN
Tissue specificity：Widely expressed. Expressed at higher level in lung and brain. Weakly expressed in spleen. {ECO:0000269|PubMed:11331020, ECO:0000269|PubMed:9637690}.
Induction：
Developmental stage：At 7.5 dpc, it is expressed in all three germ layers, although it appears to be more expressed in the embryonic ectoderm and the node. Widespread expression persists at 8.5 dpc, although it is clearly expressed at higher level in rhombomeres 2 and 4 and branchial arches 1 and 2 (which are populated by neural crest from these rhombomeres). At 10.5 dpc, the dorsal and ventral aspects of the neural tube, brain and midbrain-hindbrain junction show the most intense expression. A day later in development, elevated expression is found in the floor plate and the sclerotome. At 12.5 dpc, both the floor plate and the roofplate exhibit strong expression as the mesenchyme of the limb and of the developing whisker follicles. At 13.5 dpc, it is predominantly expressed in embryonic mesenchyme, especially at sites of epithelial-mesenchymal interactions such as the developing teeth and whisker follicles. Strong expression is also apparent in the perichondria of the cartilaginous skeleton, an important site for the regulation of skeletal differentiation.
Protein families：Sulfotransferase 3 family