NPAS4_MOUSE Q8BGD7
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UniProt:Q8BGD7
Recommended name：Neuronal PAS domain-containing protein 4
EC number：
Alternative names：(Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS)
Cleaved into：
GeneID：225872
Gene names (primary )：Npas4
Gene names (synonym )：Nxf
Gene names (ORF )：
Length：802
Mass：87286
Sequence：MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTMPSALDADRLFRCRFNTSKSLRRQSSGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPGPASLFLAMFQSRHAKDLALLDVSESVLIYLGFERSELLCKSWYGLLHPEDLAQASSQHYRLLAESGDIQAEMVVRLQAKHGGWTWIYCMLYSEGPEGPFTANNYPISDTEAWSLRQQLNSEDTQAAYVLGTPAVLPSFSENVFSQEQCSNPLFTPSLGTPRSASFPRAPELGVISTPEELPQPSKELDFSYLPFPARPEPSLQADLSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPPPSSSLQEQLTPSTVTFSEQLTPSSATFPDPLTSSLQGQLTESSARSFEDQLTPCTSSFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLNSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHYTEKEQNEIDRLIQQISQLAQGVDRPFSAEAGTGGLEPLGGLEPLNPNLSLSGAGPPVLSLDLKPWKCQELDFLVDPDNLFLEETPVEDIFMDLSTPDPNGEWGSGDPEAEVPGGTLSPCNNLSPEDHSFLEDLATYETAFETGVSTFPYEGFADELHQLQSQVQDSFHEDGSGGEPTF
Tissue specificity：Mainly expressed in brain (PubMed:14701734, PubMed:15363889). Expressed in the limbic system and olfactory bulb (PubMed:15363889, PubMed:25088421). Specifically expressed in CA1 and CA3 region of the hippocampus after contextual learning (at protein level) (PubMed:22194569, PubMed:23029555). Also expressed in pancreatic beta cells (PubMed:26663079). {ECO:0000269|PubMed:14701734, ECO:0000269|PubMed:15363889, ECO:0000269|PubMed:22194569, ECO:0000269|PubMed:23029555, ECO:0000269|PubMed:25088421, ECO:0000269|PubMed:26663079}.
Induction：Induced upon calcium influx (PubMed:26663079). Expression is regulated by neuronal activity (at protein level) (PubMed:18815592, PubMed:22194569, PubMed:24201284, PubMed:24855953). Induced in CA3 region of the hippocampus after contextual learning (PubMed:22194569). Induced following sensory input in newborn olfactory bulb interneurons (PubMed:25088421). Induced in the medial prefrontal cortex cells of the brain following experiences with positive valence (PubMed:27238022). Induced in pancreatic beta cells in response to calcium influx (PubMed:26663079). Down-regulated by REST (PubMed:24291638). Transcripts are regulated by a subset of miRNAs, such as miR-203, miR-224 and miR-744, that bind to its 3'-UTR region and down-regulate its expression (PubMed:24291638, PubMed:27189618). {ECO:0000269|PubMed:18815592, ECO:0000269|PubMed:22194569, ECO:0000269|PubMed:24201284, ECO:0000269|PubMed:24291638, ECO:0000269|PubMed:24855953, ECO:0000269|PubMed:25088421, ECO:0000269|PubMed:26663079, ECO:0000269|PubMed:27189618, ECO:0000269|PubMed:27238022}.
Developmental stage：
Protein families：