TARM1_MOUSE B6A8R8
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UniProt:B6A8R8
Recommended name：T-cell-interacting, activating receptor on myeloid cells protein 1
EC number：
Alternative names：(OSCAR-like transcript-2 protein) (OLT-2)
Cleaved into：
GeneID：245126
Gene names (primary )：Tarm1
Gene names (synonym )：Gm9904
Gene names (ORF )：
Length：288
Mass：31392
Sequence：MISRLLSLLCLRLCVGQTDIPENGSPPKPSLSAWPSTVLPTKSHVTMQCKSPTPSKYFILKKEGFALNSVKPYNLTEETADFHFTDLRQNDGGHYTCEYYSKWPHDTPSHPSNALFLLVTGYLPQPSFQAHHRGTVTAGSKVTLQCQKAGSVLGPVKFALLKVGHSTPVQTRSSTGMVSDFSLQNVTARDSGEYSCVYYQAKAPYRASGPSNLLEISVIDNHLPQDLAASTFPPQLTATSPKTPGTMTEGYTVDNLIRVGVAAAILLIVGGFLVEAWHSERLSPNKPW
Tissue specificity：Expressed in lung, uterus, lymph nodes, spleen, thymus and bone marrow. Expressed in bone marrow CD11b(+)Gr-1(+) granulocyte precursors and mature neutrophils. {ECO:0000269|PubMed:26311901}.
Induction：Up-regulated in CD11b(+)Ly6G(+) and CD11b(+)Ly6C(+) neutrophils upon S.typhimurium bacterial infection. Up-regulated in CD11b(+)Ly6C(intermediate)Ly6G(high)MHCI(-) neutrophils and CD11b(+)Ly6C(high)Ly6G(low)MHCII(+) inflammatory monocytes in response to TLR4 ligand lipopolysaccharide (LPS) stimulation. Up-regulated in cultured macrophages and dendritic cells by TLR4 ligand LPS, TLR2-TLR6 ligand MALP-2 (a bacterial lipopeptide from M.fermentans), TLR1-TLR2 ligand Pam3CSK4 (a synthetic bacterial lipopeptide), TLR3 ligand polyinosinic:polycytidylic acid (poly(I:C), a double-stranded RNA synthetic analog) and TLR7 synthetic ligand imiquimod (R-837). {ECO:0000269|PubMed:26311901}.
Developmental stage：
Protein families：