MSLN_MOUSE Q61468
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UniProt:Q61468
Recommended name：Mesothelin
EC number：
Alternative names：(Pre-pro-megakaryocyte-potentiating factor)
Cleaved into：Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form
GeneID：56047
Gene names (primary )：Msln
Gene names (synonym )：Mes Mpf
Gene names (ORF )：
Length：625
Mass：69423
Sequence：MALPTARPLLGSCGSPICSRSFLLLLLSLGWIPRLQTQTTKTSQEATLLHAVNGAADFASLPTGLFLGLTCEEVSDLSMEQAKGLAMAVRQKNITLRGHQLRCLARRLPRHLTDEELNALPLDLLLFLNPAMFPGQQACAHFFSLISKANVDVLPRRSLERQRLLMEALKCQGVYGFQVSEADVRALGGLACDLPGKFVARSSEVLLPWLAGCQGPLDQSQEKAVREVLRSGRTQYGPPSKWSVSTLDALQSLVAVLDESIVQSIPKDVKAEWLQHISRDPSRLGSKLTVIHPRFRRDAEQKACPPGKEPYKVDEDLIFYQNWELEACVDGTMLARQMDLVNEIPFTYEQLSIFKHKLDKTYPQGYPESLIQQLGHFFRYVSPEDIHQWNVTSPDTVKTLLKVSKGQKMNAQAIALVACYLRGGGQLDEDMVKALGDIPLSYLCDFSPQDLHSVPSSVMWLVGPQDLDKCSQRHLGLLYQKACSAFQNVSGLEYFEKIKTFLGGASVKDLRALSQHNVSMDIATFKRLQVDSLVGLSVAEVQKLLGPNIVDLKTEEDKSPVRDWLFRQHQKDLDRLGLGLQGGIPNGYLVLDFNVREAFSSRASLLGPGFVLIWIPALLPALRLS
Tissue specificity：Highly expressed in lung and heart. Expressed at low levels in spleen, liver, kidney and testis. Present in lung (at protein level). {ECO:0000269|PubMed:10733593}.
Induction：By WNT1 but not by WNT5A in mammary epithelial cells. {ECO:0000269|PubMed:12697065}.
Developmental stage：Expressed at 7 dpc, down-regulated at 11 dpc, re-expressed at 15 dpc and peaks at 17 dpc. Present in embryonic diaphragm (at protein level). {ECO:0000269|PubMed:10733593, ECO:0000269|PubMed:14676194}.
Protein families：Mesothelin family