Type I Interferon Induction and Signaling
The innate immune system uses pattern recognition receptors (PRRs) that detect conserved pathogen-associated molecular patterns (PAMPs), such as cytoplasmic double-stranded RNA, to detect and initiate an immune response to viral infection. Detection of virus by PRRs leads to phosphorylation and nuclear translocation of IRF-3 and IRF-7, resulting in upregulation of type I interferons, which include IFN-α and IFN-β. Type I interferons signal through the interferon α/β receptor (IFNAR), leading to phosphorylation and activation of Stat1 and Stat2, which form a complex with IRF-9. This complex translocates to the nucleus where it induces transcription of interferon response genes including viral restriction factors, such as MX1, that limit viral replication and propagation.
Cell-intrinsic and immunological anticancer effects of type I IFN responses.
Relevant Antibodies
| Catalog# | Product Name | Application | Reactivity |
|---|---|---|---|
| AMRe05927 | Phospho-IRF3 (S386) (7S3) Rabbit Monoclonal Antibody | WB,ICC/IF | Human |
| AMRe21447 | IRF3 Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| APRab04872 | IRF-7 (phospho-Ser477) Rabbit Polyclonal Antibody | WB,IHC-P | Human,Rat,Mouse |
| AMRe12748 | IRF7 (1D12) Rabbit Monoclonal Antibody | WB,IP | Human |
| AMRe83905 | Interferon beta Rabbit Monoclonal | WB,IP | Human |
| AMRe06017 | Phospho-STAT1 (S727) (6Q18) Rabbit Monoclonal Antibody | WB,IHC-P,IF-P | Human,Mouse,Rat |
| AMRe21600 | STAT1 α Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| AMRe12750 | IRF-9 (3N8) Rabbit Monoclonal Antibody | WB,ICC/IF,FC | Human |
| AMRe21071 | MX1 Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| APS0635 | HRP-conjugated Polyclonal Goat Anti-Rabbit IgG(H+L) Secondary Antibody | ELISA,WB,Dotblot | Mouse |
| AMRe80004 | GAPDH (12R9) Rabbit Monoclonal Antibody | WB,ELISA | Human,Mouse,Rat,Rabbit,Dog,Monkey |
Related Products
· Super-sensitive ECL chemiluminescent reagent
· IHC Kit
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 | Voisey Voisey is a technical support specialist at EnkiLife, proficient in immunology and cell biology. She is committed to providing customers with professional and efficient technical support. Additionally, she is involved in research on customers' fields of study and designs highly cost-effective solutions for them. |