M10L1_MOUSE Q99MV5
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UniProt:Q99MV5
Recommended name：RNA helicase Mov10l1
EC number：EC 3.6.4.13
Alternative names：(Cardiac helicase activated by MEF2 protein) (Cardiac-specific RNA helicase) (Moloney leukemia virus 10-like protein 1 homolog) (MOV10-like protein 1 homolog)
Cleaved into：
GeneID：83456
Gene names (primary )：Mov10l1
Gene names (synonym )：Champ
Gene names (ORF )：
Length：1187
Mass：132792
Sequence：MIDDLIYFSNDAVTSTVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWEDDSKNSSKGLSDSSPRVLIGCVTSMLEGAGYISQTTYFSLESVCEGFHPCKGDWVEAEYWIRPGTWSSEAISVKPLRYKRVDKVCISSLCGRNGVIEDSIFFSLDSLKLPEGYIPRRHDIVNAVVVESSQSCYIWRALCMTPVKRDATLGEAPQEPYGALLLKNKGDIEVTRMTSFGTLKEGESKSIVIWIENKGKFSRELVSCRLANWDKAHQFRFETQGRSKSCPGAAAGSVPEGENVNSLNHHREDKTDEIPESRLANSTEISPDGCACKEESREKGNTPEKQEPEPGGLIPPGEKTHIVVTCSAKNPGRCKELLLLCFSDFLIGRHLEVSVVSSEEALIAVREPFSWKKPKSSQTLVSAKTTVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIHAEIELKEYNMSRVVLKRKGDLLVLEVPGLAESRPSLYAGDKLILKSQEYNGHVIEYIGYVMEIHEEDVTLKLNPGFEQMYNFEPMDVEFTYNRTTSRRCHYALEQVIHLGVKVLFPEEIILQSPQVTGNWSLAQDTKNDGQSITNITRNDGQSMTKVTRNDSQSITNIIRNDGQSITNVTRNDGQPITKVTRNNSQSITNITRNDGQPITKNKKTVKDQTKHTTEERHVGTTDQPEKASSTAETMDEIQIPKARDKEFFNPVLNENQKLAVRRILSGDCRPLPYILFGPPGTGKTVTIIEAVLQVHYALPDSRILVCAPSNSAADLVCLRLHESKVPKPAAMVRVNATCRFEETIIDAIKPYCRDGEDIWRASRFRIIITTCSSAGLFYQIGVRVGYFTHVFVDEAGQASEPECLIPLGLISDINGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDENAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELEVCADPKVVTSLLGWEKLPRKGFPLIFHGVRGNEAREGRSPSWFSPAEAVQVMRYCCLLARSVSSQVSSKDIGVITPYRKQVEKIKILLRNVDLTDIKVGSVEEFQGQEYLVIVISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIILGNPHVLVRDPCFGALLEYSVSNGVYTGCDLPPELQALQK
Tissue specificity：Isoform 1: Specifically expressed in testis (PubMed:12754203). Isoform 1: In testis, present in pachytene spermatocytes but absent in postmeiotic spermatids (at protein level) (PubMed:20534472, PubMed:20547853). Isoform 2: Present in cardiomyocytes (at protein level) (PubMed:11279525). Isoform 2: Heart specific (PubMed:11854500). Isoform 3: Heart specific and is specifically expressed in cardiac myocytes (PubMed:12754203). {ECO:0000269|PubMed:11279525, ECO:0000269|PubMed:11854500, ECO:0000269|PubMed:12754203, ECO:0000269|PubMed:20547853}.
Induction：Isoform 2: Activated by MEF2C. Isoform 3: Activated by Nkx2-5. {ECO:0000269|PubMed:12754203}.
Developmental stage：[Isoform 2]: Expression is first observed in the linear heart tube at 8 dpc. The highest expression is in the region that will give rise to the ventricular segments. At 9.5 dpc, the ventricular expression is maintained in the looped heart tube. In the adult, expression is observed exclusively within myocardial cells. {ECO:0000269|PubMed:11854500}.
Protein families：DNA2/NAM7 helicase family, SDE3 subfamily