FUT2_MOUSE Q9JL27
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UniProt:Q9JL27
Recommended name:Galactoside alpha-(1,2)-fucosyltransferase 2
EC number:
Alternative names:(Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase) (MFUT-II) (Secretory blood group protein 2) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)
Cleaved into:
GeneID:14344
Gene names (primary ):Fut2
Gene names (synonym ):Sec2
Gene names (ORF ):
Length:347
Mass:39243
Sequence:MASAQVPFSFPLAHFLIFVFVTSTIIHLQQRIVKLQTLSEKELQAVQMSSPNAARTDMQQSAKLQGIFTINSIGRLGNQMGEYATLFALARMNGRLAFIPESMHNALAPIFRISLPVLHSDTARRIPWQNYHLNDWMEERYRHIPGQYVRFTGYPCSWTFYHHLRPEILKEFTLHDHVREEAQAFLRGLRVNGSQPSTFVGVHVRRGDYVHVMPKVWKGVVADRGYLEKALDRFRARYSSPVFVVTSNGMAWCRENINTSLGDVVFAGNGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGDTIYLANYTLPDSPFLKIFKPAAAFLPEWMGIPADLSPLLKH
Tissue specificity:Expressed in stomach, colon, ovary and uterus, specifically in luminal uterine epithelium (PubMed:11323419, PubMed:11368156). Expressed in various tissues including heart, liver, kidney, testis, epididymis, small intestine,and cecum (PubMed:11368156). Expressed in duodenum, jejunum and ileum (PubMed:14967068). {ECO:0000269|PubMed:11323419, ECO:0000269|PubMed:11368156, ECO:0000269|PubMed:14967068}.
Induction:Induced after microbes administration in the intestinal epithelia, particularly in the duodenal and jejunal epithelia (PubMed:11368156, PubMed:14967068). Down-regulated by androgen in the caput epididymis (PubMed:24284406). {ECO:0000269|PubMed:11368156, ECO:0000269|PubMed:14967068, ECO:0000269|PubMed:24284406}.
Developmental stage:Detected at highest levels in proestrus and estrus, with 10- to 12-fold increases over early diestrus. {ECO:0000269|PubMed:11323419}.
Protein families:Glycosyltransferase 11 family