LEF1_MOUSE P27782
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UniProt:P27782
Recommended name：Lymphoid enhancer-binding factor 1
EC number：
Alternative names：(LEF-1)
Cleaved into：
GeneID：16842
Gene names (primary )：Lef1
Gene names (synonym )：Lef-1
Gene names (ORF )：
Length：397
Mass：44059
Sequence：MPQLSGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNESEIIPASNGHEVVRQAPSSQEPYHDKAREHPDEGKHPDGGLYNKGPSYSSYSGYIMMPNMNSDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNSKQGMSRHPPAPEIPTFYPLSPGGVGQITPPIGWQGQPVYPITGGFRQPYPSSLSGDTSMSRFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESTSGTGPRMTAAYI
Tissue specificity：Expressed in Vgamma1.1 and Vgamma2 gamma-delta T-cells, however not expressed in gamma-delta thymocytes fated for Il17a expression (at protein level) (PubMed:17218525, PubMed:23562159). Expressed in alpha-beta T-cell lineages (PubMed:17218525). Expressed in the thymus (PubMed:1827423). Found in distinct epithelial cell compartments of the skin and is abundant in the hair-producing progenitors of the follicle (PubMed:10498690). {ECO:0000269|PubMed:10498690, ECO:0000269|PubMed:17218525, ECO:0000269|PubMed:1827423, ECO:0000269|PubMed:23562159}.
Induction：
Developmental stage：Detected throughout the basal layer, in ectodermal placodes and the underlying dermal condensates in embryonic skin, and in epithelium and mesenchyme from early hair germs. At birth expression decreases in the basal level of the epidermis and increases in hair bulbs, in particular in matrix and precortex. At day 6-9 expression is concentrated in follicle bulbs and in the hair shaft in a concentric ring of hair-keratin-expressing cells derived from the precortex. Detected in dermal papilla throughout the hair cycle, and in a subset of cells emanating from the bulge to form the secondary hair germ.
Protein families：TCF/LEF family