DOC10_MOUSE Q8BZN6
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UniProt:Q8BZN6
Recommended name：Dedicator of cytokinesis protein 10
EC number：
Alternative names：(Zizimin-3)
Cleaved into：
GeneID：210293
Gene names (primary )：Dock10
Gene names (synonym )：Kiaa0694 Ziz3
Gene names (ORF )：
Length：2150
Mass：245758
Sequence：MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQEKPRLLDPLDYETVIEELEKTYRDDPLQDLLFFPSDDFSTATVSWDIRTLYSTVPEEAEHRAESLLVKEACKFYSSQWYVVNYKYEQYSGDIRQLPRAEHKPEKLPSHSFEVDHEDADKDEDTTSHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGRKSAELAELGLDPLDNCVTCECTLEETDSSENSLHPDFAKYLTETEDTVKTTRNMGRLNLFSLDPDIDTLKLQKRDSFENELMIKPFEEKAAKRIMIICRALNFNLQGCVTENEYDPVTNIEPFFVSVALYDLRDNRKISADFHVDLNHPAVRQMLSGTPPALENGNIDTGTPRQSEEPHIKGLPEEWLKFPKQAVFSVSDPHSEIVLVAKVEKVLMGNIGSGAEPYIKNPDSNKFAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLYRQESSKMSSEDLLKLVSDYRRADRISKMQSIPGSLDIAVDNIPLEHPNCVTSSFIPVKPFNVSAQSEPTVEVEEFIYDSTKYCRPYRVYKNQIYVYPKHLKYDSQKCFNKARNITVCIEFKNSDDDGAKPMKCIYGKPGGPLFTSSAYTAVLHHSQNPDFSDEVKIELPTQLHGKHHLLFSFYHITCDINAKANAKKKEALETSVGYAWLPLMKHDQIASQEYNIPIATTLPPNYLSIQDPTSAKHGGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNAFFRQCQKREKDMSQSPTSSFVRACKNLLNVDKIHSIMSFLPIILNQLFKILVQNEEDEITATVTRVLADIVAKCHEEQLDHSVQSYIKFVFKTKSYKERTIHEELAKNLSDLLKSNDSTIVKHVLEHSWFFFAIILKSMAQHLIDTNKIQLPRAQRFPESYQSELDNLVMGLCDHVIWKCKEAPEETKRANHSVARFLKRCFTFMDRGFVFKMVNNYISMFSSGEFKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESIRELHASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDIRHLALAVLKNLMAKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQTQTSMKHATSVDTSFSKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTTEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISDETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHTTSGHEGHKQHRSQTLPIIRGKNALSNPKLLQMLDNSMNSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQVHQRQLQQSDCQNSLMKRVFDTYMLFFQVNQSASALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRLTQMEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYWKMEKICTPPLLPEDTQPCDSNLLLTTPGGGSMFSMGWPAFLSITPNIKEEGAMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQAVGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVAEQCKRRTVLTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSRKVSELNQLCTTEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSAIMNEQ
Tissue specificity：Expressed in brain, lung, spleen, mesenteric lymph nodes (MLN) and thymus (PubMed:15710388, PubMed:25729399). Expressed by B and T splenocytes (PubMed:21514340). In brain, expressed by Purkinje cells during postnatal development and hippocampal neurons (PubMed:25851601). {ECO:0000269|PubMed:15710388, ECO:0000269|PubMed:21514340, ECO:0000269|PubMed:25729399, ECO:0000269|PubMed:25851601}.
Induction：Isoform 4 (but not isoform 1) is highly induced by IL4 in B splenocytes, but not T splenocytes. {ECO:0000269|PubMed:21514340}.
Developmental stage：At early postnatal stages, expressed broadly in the cerebellum and from P15 the expression becomes restricted to Purkinje cells. {ECO:0000269|PubMed:25851601}.
Protein families：DOCK family