DRGX_MOUSE   Q8BYH0


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UniProt:Q8BYH0

Recommended name:Dorsal root ganglia homeobox protein

EC number:

Alternative names:(Dorsal root ganglion 11) (Homeobox protein DRG11) (Paired-related homeobox protein-like 1)

Cleaved into:

GeneID:107751

Gene names  (primary ):Drgx

Gene names  (synonym ):Drg11 Prrxl1

Gene names  (ORF ):

Length:263

Mass:28717

Sequence:MFYFHCPPQLEGTAPFGNHSTGDFDDGFLRRKQRRNRTTFTLQQLEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRKTERGASDQEPGAKEPMAEVTPPPVRNINSPPPGDQTRSKKEALEAQQSLGRTVGPTGPFFPSCLPGTLLNTATYAQALSHVASLKGGPLCSCCVPDPMGLSFLPTYGCQSNRTASVAALRMKAREHSEAVLQSANLLPSTSSSPGPASKQAPPEGSQDKTSPTKEQSEGEKSV

Tissue specificity:Expressed in the dorsal horn of the spinal cord and dorsal root ganglia. Isoform 1 is higher expressed than isoform 2 both in the dorsal root ganglia and in the spinal cord. Isoform 2 is exclusively localized in neurons primarily involved in the processing of the pain somatosensory modality. {ECO:0000269|PubMed:11498051, ECO:0000269|PubMed:19598127}.

Induction:

Developmental stage:First detected at 12.5 dpc in newly generated neurons adjacent to the ventricular zone of the dorsal spinal cord. Later expressed in lateral region of the dorsal spinal cord and dorsal root ganglia at 13.5 dpc with increased levels at 15.5 dpc. {ECO:0000269|PubMed:11498051}.

Protein families:Paired homeobox family


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