ENPP6_MOUSE Q8BGN3
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UniProt:Q8BGN3
Recommended name：Glycerophosphocholine cholinephosphodiesterase ENPP6
EC number：EC 3.1.4.-
Alternative names：(GPC-Cpde) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) (E-NPP 6) (NPP-6)
Cleaved into：
GeneID：320981
Gene names (primary )：Enpp6
Gene names (synonym )：
Gene names (ORF )：
Length：440
Mass：50618
Sequence：MAAKLWTFLLGFGLSWVWPASAHRKLLVLLLDGFRSDYISEDALASLPGFREIVNRGVKVDYLTPDFPSLSYPNYYTLMTGRHCEVHQMIGNYMWDPRTNKSFDIGVNRDSLMPLWWNGSEPLWITLMKARRKVYMYYWPGCEVEILGVRPTYCLEYKTVPTDINFANAVSDALDSLKSGRADLAAIYHERIDVEGHHYGPSSPQRKDALRAVDTVLKYMIQWIQDRGLQQDLNVILFSDHGMTDIFWMDKVIELSNYISLDDLQQVKDRGPVVSLWPVPGKHSEIYHKLRTVEHMTVYEKESIPNRFYYKKGKFVSPLTLVADEGWFIAESREMLPFWMNSTGKREGWQRGWHGYDNELMDMRGIFLAIGPDFKSNFRAAPIRSVDVYNIMCHVAGITPLPNNGSWSRVVCMLKGQTSSAPPTPLNSCALVLILLLYFV
Tissue specificity：Predominantly expressed in kidney with a lesser expression in brain and heart (PubMed:15788404, PubMed:26888014). In the brain and spinal cord, mainly expressed in the white matter. In oligodendrocytes, is predominantly detected in the myelin sheath. In the kidney, is predominantly expressed in the luminal side of the renal tubule in the cortex and in the proximal renal tubules. It is expressed in liver sinusoidal endothelial cells (PubMed:26888014). {ECO:0000269|PubMed:15788404, ECO:0000269|PubMed:26888014}.
Induction：
Developmental stage：At postnatal day 2 (P2) and P4, is detected in immature oligodendrocytes, where it was predominantly found both in the processes and cell bodies. In contrast, at P12 and P14, it is found mainly in myelin sheaths. {ECO:0000269|PubMed:26888014}.
Protein families：Nucleotide pyrophosphatase/phosphodiesterase family