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MS4A1 Molecular Target Information Overview


  • Molecular name: MS4A1, membrane spanning 4-domains A1
  • Gene family: CD molecules; Membrane spanning 4-domains
  • Other names: B1; Bp35; FMC7
  • Former name: CD20
  • Alias: membrane-spanning 4-domains, subfamily A, member 1


    • MS4A1 molecular target review


    CD20 is a phosphorylated protein molecule with a molecular weight of 33-37 kD, which is expressed in B lymphocytes and their precursors, but not in the earliest progenitor cells, and weakly expressed in follicular dendritic cells and a small number of T cells. It is mainly involved in regulating the proliferation and differentiation of B lymphocytes and plays an important role in the immune system. Due to the expression characteristics of CD20 on the surface of malignant B cells and the lack of endocytosis when bound to antibodies, it has been used as a target for immunotherapy of Hodgkin's lymphoma.


    Human MS4A1 Molecular Target Information


    Molecular name: MS4A1, membrane spanning 4-domains A1


    Alias:

    • B-lymphocyte antigen CD20
    • B-lymphocyte cell-surface antigen B1
    • B-lymphocyte surface antigen B1
    • B1
    • Bp35
    • CD20
    • CD20 antigen
    • CD20 receptor
    • CVID5
    • FMC7
    • LEU-16
    • leukocyte surface antigen Leu-16
    • membrane-spanning 4-domains subfamily A member 1
    • membrane-spanning 4-domains, subfamily A, member 1
    • MGC3969
    • MS4A2
    • S7

    Gene sequence:NCBI_Gene: 931

    Protein sequence:UniProtKB: P11836


    Human MS4A1 target molecular function (prediction)


    Enables identical protein binding activity and immunoglobulin binding activity. Involved in several processes, including B cell receptor signaling pathway; calcium ion transport; and protein tetramerization. Located in cell surface; nucleoplasm; and plasma membrane raft. Implicated in common variable immunodeficiency.


    Mouse Ms4a1 molecular target information


    Molecular name:Ms4a1, membrane-spanning 4-domains, subfamily A, member 1


    Alternate names:

    • AA960661
    • Cd20
    • CD20 antigen
    • expressed sequence AA960661
    • Ly-44
    • lymphocyte antigen 44


    Gene sequence:NCBI_Gene: 12482

    Protein sequence:


    Mouse Ms4a1 Target Molecular Function (Prediction)


    Predicted to enable epidermal growth factor receptor binding activity; identical protein binding activity; and immunoglobulin binding activity. Involved in calcium ion import into cytosol. Acts upstream of or within response to bacterium. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; Orthologous to human MS4A1 (membrane spanning 4-domains A1).


    Rat Ms4a1 molecular target information


    Molecular name: Ms4a1, membrane spanning 4-domains A1

    Alias:

    • B-lymphocyte antigen CD20
    • LOC309217
    • membrane-spanning 4-domains, subfamily A, member 1

    Gene sequence:NCBI_Gene: 309217

    Protein sequence:UniProtKB: D4A4Y3


    Rat Ms4a1 target molecular function (prediction)


    Enables epidermal growth factor receptor binding activity. Predicted to be involved in several processes, including B cell receptor signaling pathway; calcium ion transport; and protein tetramerization. Predicted to act upstream of or within response to bacterium. Predicted to be located in external side of plasma membrane; nucleoplasm; Orthologous to human MS4A1 (membrane spanning 4-domains A1).