NFIL3_MOUSE O08750
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UniProt:O08750
Recommended name:Nuclear factor interleukin-3-regulated protein
EC number:
Alternative names:(E4 promoter-binding protein 4) (Embryo implantation-related NFIL3/E4BP4-like transcription factor)
Cleaved into:
GeneID:18030
Gene names (primary ):Nfil3
Gene names (synonym ):E4bp4
Gene names (ORF ):
Length:462
Mass:50943
Sequence:MQLRKMQTIKKEPAPLDPTSSSDKMLLLNSALAEVAEDLASGEDLLLNEGSMGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQDYQTSKAAVSSFVDEHEPAMVAGSCISVIKHSPQSSLSDVSEVSSVEHTQESPAQGGCRSPENKFPVIKQEPVELESFAREAREERGTYSTSIYQSYMGSSFSTYSHSPPLLQVHGSTSNSPRTSEADEGVVGKSSDGEDEQQVPKGPIHSPVELQRVHATVVKVPEVNPSALPHKLRIKAKAMQVKVEALDSEFEGMQKLSSPADAIAKRHFDLEKHGTSGMAHSSLPPFSVQVTNIQDWSLKSEHWHHKELSSKTQSSFKTGVVEVKDGGYKVSEAENLYLKQGIANLSAEVVSLKRFIATQPISASDSR
Tissue specificity:Expressed in suprachiasmatic nucleus and liver (at protein level). Expressed in suprachiasmatic nucleus, hippocampus, gyrus dentatus, piriform cortex, internal granular layer of olfactory bulb, dorsomedial hypothalamic nucleus, pontine nuclei, granular layer of cerebellum, liver and calvariae osteoblasts. {ECO:0000269|PubMed:11316793, ECO:0000269|PubMed:12743120}.
Induction:Expression is regulated by circadian rhythms. Up-regulated by parathyroid hormone (PTH) (at protein level). Up-regulated by IL-3, forskolin, 8-bromo-cAMP, phorbol myristate acetate and PTH in primary osteoblasts and calvariae. {ECO:0000269|PubMed:12743120, ECO:0000269|PubMed:15087429, ECO:0000269|PubMed:9122243}.
Developmental stage:
Protein families:BZIP family, NFIL3 subfamily