NAC3_MOUSE S4R2P9
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UniProt:S4R2P9
Recommended name：Sodium/calcium exchanger 3
EC number：
Alternative names：(Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3)
Cleaved into：
GeneID：110893
Gene names (primary )：Slc8a3
Gene names (synonym )：Ncx3
Gene names (ORF )：
Length：928
Mass：102984
Sequence：MAWLRLQPLTSAFLHFGLVTFVLFLNCLRAEAGDSGDVPSAGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFVTAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNFTPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKTSSMSEVHTDEPEDFASKVFFDPCSYQCLENCGAVLLTVVRKGGDISKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRVEEEQLAEGMLPAILNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDAYGELEFKNDETVKTIHIKVIDDKAYEKNKNYVIEMMGPRMVDMSVQKALLLSPEVTDRKLTVEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAGGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFVVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWAMQGQEFHVSAGTLAFSVTLFTIFAFVCLSVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF
Tissue specificity：Detected in gray and white matter in the spinal cord (PubMed:21959935). Detected in hippocampus neurons (PubMed:21593315). Detected in brain cortex neurons (PubMed:24101730). Detected in skeletal muscle (at protein level) (PubMed:14722618). Isoform 1 and isoform 2 are highly expressed in brain; levels are higher for isoform 2 (PubMed:24616101). Isoform 1 and isoform 2 are detected in soleus muscle; levels are higher for isoform 1 (PubMed:24616101). Detected in gastrocnemius muscle (PubMed:14722618). {ECO:0000269|PubMed:14722618, ECO:0000269|PubMed:21593315, ECO:0000269|PubMed:21959935, ECO:0000269|PubMed:24101730, ECO:0000269|PubMed:24616101}.
Induction：Down-regulated by hypoxia combined with glucose deprivation (at protein level). {ECO:0000269|PubMed:24101730}.
Developmental stage：
Protein families：Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC8 subfamily