TXND2_MOUSE Q6P902
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UniProt:Q6P902
Recommended name：Thioredoxin domain-containing protein 2
EC number：
Alternative names：(Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4)
Cleaved into：
GeneID：213272
Gene names (primary )：Txndc2
Gene names (synonym )：Sptrx Sptrx1 Trx4
Gene names (ORF )：
Length：515
Mass：57767
Sequence：MTLNNGGKANERGSNENPLQALSKNEAFLVPEFLDTAQSKEKAIASKVSNTLHMSTEESEFPQQVSSTPMFSENTVHPRHEVSPKPSSKNTQLKQENISKSSGYSKQTNYSNTPKSLAKTTHPKQGSTLKPATNSTHYREDDIPKSSEDIIQPKKGDRPKSSEDIIQSKKEDRPKSSEDIIQSKKEDRPKSSEDIIQSKKEDRPKSSEDIIQSKKEDRPKSSEDIIQPKKEDRPKSSEDSVPSKKGDRPKSSEDSVQPKKEDRPKSSEDSVQSKEGEVHKPLKDSIQSKETKVPKSPQDSIQSKEDKTHRPLKDSVQSKESEEPKSSHESIQSKEDKIHKPLKDSIPSKEGDIPKSPEDTIQSQEEITASEEDTIQSQEGNTIKSSEEDVQLSESKLLGLGAEIETLEEGLVRVIKDKEEFEEVLKDAGEKLVAVDFSAAWCGPCRMMKPLFHSLSLKHEDVIFLEVDTEDCEQLVQDCEIFHLPTFQFYKNEEKVGEFSGALVGKLERSISELK
Tissue specificity：Testis-specific. Strongly expressed in the testicular seminiferous tubules, mostly in the round spermatids. {ECO:0000269|PubMed:12149401, ECO:0000269|PubMed:12390887}.
Induction：
Developmental stage：Expressed during spermiogenesis, restricted to the postmeiotic phase of spermatogenesis. First detected in elongating spermatids tails during steps 9 and 10 and is prominent in this region during steps 11-16. Also weakly present in the cytoplasmic lobe of these spermatids. During the last steps of spermiogenesis (steps 17-19), it strongly diminishes in the tail but appears to increase or become concentrated in the shrinking cytoplasmic lobe. By the last step of spermiogenesis (late step 19), cytoplasmic localization is barely detectable in the resulting residual body but still detectable in the cytoplasmic droplet (at protein level). Detected in testis of pre-pubertal animals at very low level. {ECO:0000269|PubMed:12390887, ECO:0000269|PubMed:15781233}.
Protein families：