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MMP10 molecular target information overview


  • Molecular name: MMP10, matrix metallopeptidase 10
  • Gene family: M10 matrix metallopeptidases
  • Former name: STMY2
  • Alias: matrix metalloproteinase 10 (stromelysin 2); stromelysin 2


    • Overview of MMP10 molecular targets


    Matrix metalloproteinase 10 (MMP-10), also known as stromelysin-2, is encoded by the MMP10 gene in humans. This gene is part of the MMP gene cluster located on chromosome 11q 22.3. MMP-10 degrades proteoglycans and fibronectin and plays an important role in the degradation of the extracellular matrix under various pathological conditions. MMP-10 is strongly expressed in osteoclasts and most mononuclear cells in the bone marrow, is induced by cytokines in human keratinocytes, and is also expressed in human head and neck cancer and lung cancer cells. Overexpression of MMP-10 in the corneal epithelium of diabetic patients may be a major factor in diabetic retinopathy. MMP-10 is associated with the viability and metastasis of tumor stem cells.


    Human MMP10 molecular target information


    Molecular name: MMP10, matrix metallopeptidase 10


    Alias:

    • matrix metalloprotease 10
    • matrix metalloproteinase 10 (stromelysin 2)
    • matrix metalloproteinase-10
    • MMP-10
    • SL-2
    • STMY2
    • stromelysin 2
    • stromelysin-2
    • transin 2
    • transin-2

    Gene sequence:NCBI_Gene: 4319

    Protein sequence:UniProtKB: P09238


    Human MMP10 target molecular function (prediction)


    Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within regulation of cell migration. Predicted to be located in extracellular space. Biomarker of adrenoleukodystrophy; diabetes mellitus; and end stage renal disease.


    Mouse Mmp10 molecular target information


    Molecular name: Mmp10, matrix metallopeptidase 10


    Alias:

    • AV377895
    • expressed sequence AV377895
    • stromelysin 2


    Gene sequence:NCBI_Gene: 17384

    Protein sequence:


    Mouse Mmp10 target molecular function (prediction)


    Predicted to enable metalloendopeptidase activity. Acts upstream of or within regulation of cell migration. Predicted to be located in extracellular matrix and extracellular region. Is expressed in gonad; ovary; and testis. Orthologous to human MMP10 (matrix metallopeptidase 10).


    Rat Mmp10 molecular target information


    Molecular name: Mmp10, matrix metallopeptidase 10

    Alias:

    • matrix metallopeptidase 10 (stromelysin 2)
    • matrix metalloproteinase 10
    • matrix metalloproteinase-10
    • MMP-10
    • SL-2
    • stromelysin 2
    • stromelysin-2
    • transformation-associated protein 34A
    • transin-2

    Gene sequence:NCBI_Gene: 117061

    Protein sequence:


    Rat Mmp10 target molecular function (prediction)


    Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within regulation of cell migration. Predicted to be located in extracellular matrix and extracellular region. Orthologous to human MMP10 (matrix metallopeptidase 10).