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ITGAX molecular target information overview


  • Molecular name: ITGAX, integrin subunit alpha receptor 4 subunit; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit)


    • ITGAX molecular target review


    CD11c is known as complement receptor 4 (CR4), a member of the CD11/CD18 family of adhesion molecules, a type I transmembrane glycoprotein, and is highly expressed on the surface of myeloid DCs. As a positive regulatory factor, CD11c participates in the adhesion and migration of DCs, antigen recognition and presentation, and activates CD4+ and CD8+ T cells, regulating the occurrence of immune responses, and plays an important role in infection and anti-tumor immunity.


    Human ITGAX molecular target information


    Molecular name: ITGAX, integrin subunit alpha X


    Alias:

    • CD11 antigen-like family member C
    • CD11C
    • complement component 3 receptor 4 subunit
    • integrin alpha X
    • integrin alpha-X
    • integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
    • integrin, alpha X (complement component 3 receptor 4 subunit)
    • leu M5, alpha subunit
    • leukocyte adhesion glycoprotein p150,95 alpha chain
    • leukocyte adhesion receptor p150,95
    • leukocyte surface antigen p150,95, alpha subunit
    • myeloid membrane antigen, alpha subunit
    • p150 95 integrin alpha chain
    • SLEB6

    Gene sequence:NCBI_Gene: 3687

    Protein sequence:UniProtKB: P20702


    Human ITGAX target molecular function (prediction)


    Enables receptor tyrosine kinase binding activity. Involved in several processes, including heterotypic cell-cell adhesion; positive regulation of angiogenesis; and positive regulation of endothelial tube morphogenesis. Located in cell surface.


    Mouse Itgax molecular target information


    Molecular name: Itgax, integrin alpha X


    Alternate names:

    • AI449405
    • Cd11c
    • CD11C (p150) alpha polypeptide
    • expressed sequence AI449405


    Gene sequence:NCBI_Gene: 16411

    Protein sequence:


    Mouse Itgax target molecular function (prediction)


    Predicted to enable receptor tyrosine kinase binding activity. Involved in positive regulation of gene expression and positive regulation of myelination. Acts upstream of or within defense response to virus. Located in external side of plasma membrane. Is expressed in heart and hemolymphoid system. Orthologous to human ITGAX (integrin subunit alpha X).


    Rat Itgax molecular target information


    Molecular name: Itgax, integrin subunit alpha X

    Synonyms:

    • integrin alpha X
    • integrin alpha-X

    Gene sequence:NCBI_Gene: 499271

    Protein sequence:UniProtKB: D3ZWZ1


    Rat Itgax target molecular function (prediction)


    Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including positive regulation of angiogenesis; positive regulation of endothelial tube morphogenesis; and positive regulation of myelination. Predicted to act upstream of or within defense response to virus. Predicted to be located in external side of plasma membrane. Predicted to be part of integrin complex. Orthologous to human ITGAX (integrin subunit alpha X).