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RBP4 molecular target information overview


  • Molecular name: RBP4, retinol binding protein 4
  • Gene family: Lipocalins
  • Alias: retinol-binding protein 4, plasma


    • Overview of RBP4 molecular targets


    Retinol binding protein 4 (RBP4) belongs to the apolipoprotein family and is a specific carrier of retinol (vitamin A alcohol) in the blood. It transports retinol from the liver to peripheral tissues. Recently, RBP4 has been implicated as an adipokine that contributes to insulin resistance in AG4KO mice. It is secreted by adipocytes and can signal other cells when blood glucose concentrations decrease. Mutations in the RBP4 gene are associated with autosomal dominant microphthalmia, anophthalmia, and ocular histology.


    Human RBP4 molecular target information


    Molecular name: RBP4, retinol binding protein 4


    Alias:

    • MCOPCB10
    • plasma retinol-binding protein
    • PRBP
    • RBP
    • RDCCAS
    • retinol binding protein 4, plasma
    • retinol-binding protein 4
    • retinol-binding protein 4, interstitial

    Gene sequence:NCBI_Gene: 5950

    Protein sequence:UniProtKB: P02753


    Human RBP4 target molecular function (prediction)


    Enables retinol binding activity. Involved in several processes, including gluconeogenesis; positive regulation of insulin secretion; and retinol metabolic process. Located in extracellular space. Implicated in type 2 diabetes mellitus. Biomarker of type 2 diabetes mellitus.


    Mouse Rbp4 molecular target information


    Molecular name: Rbp4, retinol binding protein 4, plasma


    Alias:

    • Rbp-4
    • retinol binding protein 4, cellular


    Gene sequence:NCBI_Gene: 19662

    Protein sequence:


    Mouse Rbp4 target molecular function (prediction)


    Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; retinoid metabolic process; and terpenoid transport. Located in extracellular space. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hindlimb. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4).


    Rat Rbp4 molecular target information


    Molecular name: Rbp4, retinol binding protein 4

    Alias:

    • plasma retinol-binding protein
    • PRBP
    • RBP
    • RBPA
    • retinol binding protein 4, plasma
    • retinol-binding protein 4

    Gene sequence:NCBI_Gene: 25703

    Protein sequence:


    Rat Rbp4 target molecular function (prediction)


    Enables retinol binding activity. Involved in response to ethanol and retinol transport. Located in extracellular space. Part of protein-containing complex. Biomarker of obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4).