VISTA_MOUSE Q9D659
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UniProt:Q9D659
Recommended name：V-type immunoglobulin domain-containing suppressor of T-cell activation
EC number：
Alternative names：(Platelet receptor Gi24) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor)
Cleaved into：
GeneID：74048
Gene names (primary )：Vsir
Gene names (synonym )：Dies1 PD-1H VISTA
Gene names (ORF )：
Length：308
Mass：33559
Sequence：MGVPAVPEASSPRWGTLLLAIFLAASRGLVAAFKVTTPYSLYVCPEGQNATLTCRILGPVSKGHDVTIYKTWYLSSRGEVQMCKEHRPIRNFTLQHLQHHGSHLKANASHDQPQKHGLELASDHHGNFSITLRNVTPRDSGLYCCLVIELKNHHPEQRFYGSMELQVQAGKGSGSTCMASNEQDSDSITAAALATGACIVGILCLPLILLLVYKQRQVASHRRAQELVRMDSNTQGIENPGFETTPPFQGMPEAKTRPPLSYVAQRQPSESGRYLLSDPSTPLSPPGPGDVFFPSLDPVPDSPNSEAI
Tissue specificity：Expressed in spleen, thymus, bone marrow, lymph node, and in T-cells within the lamina propria of the small intestine (PubMed:21768399). Detected on CD4+ and CD8+ T-cells, bone marrow-derived dendritic cells (BMDCs), peritoneal macrophages, neutrophils, and natural killer (NK) cells (PubMed:21768399). In spleen and lymph nodes, highly expressed on CD4+ T-cell populations, and at lower levels on CD8+ T-cells (PubMed:21383057). In thymus, has low expression on CD4+ cells and CD8+ cells, and not detected on CD4+CD8+ cells (PubMed:21383057). Expressed in splenic and peritoneal CD11b cells (PubMed:21383057). Not detected in most B cells and NK cells (at protein level) (PubMed:21383057). Also detected at lower levels in non-hematopoeitic tissues such as heart, brain, lung, kidney, muscle, ovary, and testis (PubMed:21768399, PubMed:21383057). {ECO:0000269|PubMed:21383057, ECO:0000269|PubMed:21768399}.
Induction：Up-regulated by phorbol 12-myristate 13-acetate (PMA) and the cytokine IFNG. {ECO:0000269|PubMed:21768399}.
Developmental stage：Detected in 7-day and 17-day embryos. {ECO:0000269|PubMed:21768399}.
Protein families：