K1C18_MOUSE P05784
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UniProt:P05784
Recommended name：Keratin, type I cytoskeletal 18
EC number：
Alternative names：(Cytokeratin endo B) (Keratin D) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)
Cleaved into：
GeneID：16668
Gene names (primary )：Krt18
Gene names (synonym )：Kerd Krt1-18
Gene names (ORF )：
Length：423
Mass：47538
Sequence：MSFTTRSTTFSTNYRSLGSVRTPSQRVRPASSAASVYAGAGGSGSRISVSRSVWGGSVGSAGLAGMGGIQTEKETMQDLNDRLASYLDKVKSLETENRRLESKIREHLEKKGPQGVRDWGHYFKIIEDLRAQIFANSVDNARIVLQIDNARLAADDFRVKYETELAMRQSVESDIHGLRKVVDDTNITRLQLETEIEALKEELLFMKKNHEEEVQGLEAQIASSGLTVEVDAPKSQDLSKIMADIRAQYEALAQKNREELDKYWSQQIEESTTVVTTKSAEIRDAETTLTELRRTLQTLEIDLDSMKNQNINLENSLGDVEARYKAQMEQLNGVLLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFSLNDALDSSNSMQTVQKTTTRKIVDGRVVSETNDTRVLRH
Tissue specificity：Expressed in endoderm, intestinal epithelial cells and in most extraembryonic tissues. {ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:2416755, ECO:0000269|PubMed:2454868, ECO:0000269|PubMed:7504637}.
Induction：By retinoic acid and IL-6. {ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:2416755}.
Developmental stage：During embryogenesis, expressed in a complex spatial and temporal pattern in various embryonic epithelia. In 7.5 and 13.5 day old embryo, expressed in most endodermal epithelia, ectodermal and nascent mesodermal tissues. When the neural plate forms, expression begins in the cells of skin ectoderm, head process/notochord, periderm, whisker buds, choroid plexus and the epithelia of auditory duct and inner ear. High expression in the lining endodermal cells when the foregut and hindgut invaginations form. Expression in all three layers of the urothelium starts at day 15 in the embryo and is not visible after day 18. By day 11 and 12, the entire embryonic palatal epithelium shows expression as well as the nasal passages and the roof of the mouth; which disappears progresively from day 13 to 15. {ECO:0000269|PubMed:16973199, ECO:0000269|PubMed:7504637, ECO:0000269|PubMed:7507912}.
Protein families：Intermediate filament family