KAZD1_MOUSE Q8BJ66
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UniProt:Q8BJ66
Recommended name：Kazal-type serine protease inhibitor domain-containing protein 1
EC number：
Alternative names：(Bone and odontoblast-expressed protein 1) (Insulin-like growth factor-binding-related protein 10) (IGFBP-rP10) (IGFBP-related protein 10) (Insulin-like growth factor-binding-related protein 4)
Cleaved into：
GeneID：107250
Gene names (primary )：Kazald1
Gene names (synonym )：Bono1 Igfbprp10
Gene names (ORF )：
Length：313
Mass：34272
Sequence：MPRVFTGLPANYAAPTLALSLLLPLLLVVWTQLPVSARPSTGPDYLRRGWLRLLAEGEGCAPCRPEECAAPRGCLAGRVRDACGCCWECANLEGQLCDLDPSANFYGRCGEQLECRLDAGGDLSRGEVPEPLCVCRSQRPLCGSDGRTYAQICRLQEAARARLDANLTVVHPGPCESEPQILSQPHNIWNVTGQDVIFGCEVFAYPMASIEWRKDGLDIQLPGDDPHISVQFRGGPQKFEVTGWLQIQALRPSDEGTYRCLARNALGQAEASATLTVLTPEQLNATGFSQLQSRSLFPEEEEEAESEELGDYY
Tissue specificity：Highly expressed in the spleen. Moderately expressed in the skin, lung and urinary bladder. Weakly expressed in the brain, tongue, esophagus, stomach, large intestine, liver and bone. Expressed in osteoblastic cells during bone regeneration. Expressed in secretory osteoblasts in the tooth. {ECO:0000269|PubMed:15261838, ECO:0000269|PubMed:15555553}.
Induction：Up-regulated during the early phase of the bone regeneration. Up-regulated by BMP2 during osteoblast differentiation. {ECO:0000269|PubMed:15555553}.
Developmental stage：At 15 dpc embryos, weakly expressed in osteoblasts within the distal area of the ossification center of the mid-shaft region of the ulna and the radius. At 16 dpc embryos highly expressed in mandible, maxilla, frontal bone and ossification regions of the nasal septum. At 17 dpc embryos expression is localized to developing mandibular and maxillar bones, the frontal bones and in the nasal capsule surrounding the nasopharynx. Expression throughout the developing mandibular bone is found in 15 dpc-17 dpc embryos. Present in periosteum of the humerus at 16.5 dpc (at protein level). {ECO:0000269|PubMed:15261838, ECO:0000269|PubMed:18757743}.
Protein families：