APEX2_MOUSE Q68G58
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UniProt:Q68G58
Recommended name：DNA-(apurinic or apyrimidinic site) endonuclease 2
EC number：EC 3.1.-.-
Alternative names：(APEX nuclease 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2)
Cleaved into：
GeneID：77622
Gene names (primary )：Apex2
Gene names (synonym )：Ape2
Gene names (ORF )：
Length：516
Mass：57340
Sequence：MLRVVSWNINGIRSPLQGLACQEPSSCPTALRRVLDELDADIVCLQETKVTRDVLTEPLAIVEGYNSYFSFSRSRSGYSGVATFCKDSATPVAAEEGLSGVFATLNGDIGCYGNMDEFTQEELRVLDSEGRALLTQHKIRTLEGKEKTLTLINVYCPHADPGKPERLTFKMRFYRLLQMRAEALLAAGSHVIILGDLNTAHRPIDHCDASSLECFEEDPGRKWMDGLLSNPGDEAGPHIGLFMDSYRYLHPKQQRAFTCWSVVSGARHLNYGSRLDYVLGDRALVIDTFQASFLLPEVMGSDHCPVGAVLNVSCVPAKQCPALCTRFLPEFAGTQLKILRFLVPLEQEPVREQQVLQPSHQIQAQRQPRKACMHSTRLRKSQGGPKRKQKNLMSYFQPSSSLSQTSGVELPTLPLVGPLTTPKTAEEVATATVLEEKNKVPESKDEKGERTAFWKSMLSGPSPMPLCGGHREPCVMRTVKKTGPNFGRQFYMCARPRGPPSDPSSRCNFFLWSRPS
Tissue specificity：Expressed in lymphocytes, thymocytes and splenocytes (at protein level). Highly expressed in the thymus and weakly expressed in the bone marrow, spleen, eye, kidney, lung, brain and uterus. {ECO:0000269|PubMed:12573260, ECO:0000269|PubMed:15319281}.
Induction：Up-regulated in both the nucleus and the cytosol of B cells stimulated to switch. {ECO:0000269|PubMed:18025127}.
Developmental stage：
Protein families：DNA repair enzymes AP/ExoA family