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IL31 molecular target information overview


  • Molecular name: IL31, interleukin 31
  • Gene family: Interleukins
  • Alias: IL-31


    • Overview of IL31 molecular targets


    Interleukin 31 (IL-31) is a short-chain member of the α-helical cytokine family with a molecular weight of 24 kDa. It is mainly associated with activated T cells and is preferentially expressed by Th2 cells rather than Th1 cells. The human IL-31 cDNA encodes a 164 amino acid precursor, which includes a 23 amino acid signal peptide and a mature protein of 141 amino acids. Human and mouse IL-31 have 24% amino acid sequence homology in the mature region. IL-31 generates signals through a receptor complex, which is composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes and unstimulated epithelial cells. IL-31 signaling participates in the Jak/STAT pathway, the PI3 kinase/AKT signaling cascade, and the MAP kinase pathway. In addition, IL-31 plays a role in skin inflammation.


    Human IL31 Molecular Target Information


    Molecular name: IL31, interleukin 31


    Alias:

    • IL-31
    • interleukin-31

    Gene sequence:NCBI_Gene: 386653

    Protein sequence:UniProtKB: Q6EBC2


    Human IL31 target molecular function (prediction)


    Predicted to enable cytokine activity and oncostatin-M receptor binding activity. Predicted to be involved in immune system process and signal transduction. Located in extracellular space.


    Mouse Il31 molecular target information


    Molecular name: Il31, interleukin 31


    Alias:

    • 1700013B14Rik
    • RIKEN cDNA 1700013B14 gene


    Gene sequence:NCBI_Gene: 76399

    Protein sequence:


    Mouse Il31 target molecular function (prediction)


    Enables cytokine activity and oncostatin-M receptor binding activity. Predicted to act upstream of or within immune system process. Located in extracellular space. Orthologous to human IL31 (interleukin 31).


    Rat Il31 molecular target information


    Molecular name: Il31, interleukin 31

    Alias:

    • hypothetical protein LOC690028
    • interleukin-31
    • LOC690028

    Gene sequence:NCBI_Gene: 690028

    Protein sequence: None


    Rat Il31 target molecular function (prediction)


    Predicted to enable cytokine activity and oncostatin-M receptor binding activity. Predicted to be located in extracellular space. Orthologous to human IL31 (interleukin 31).