PERI_MOUSE P15331
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UniProt:P15331
Recommended name：Peripherin
EC number：
Alternative names：
Cleaved into：
GeneID：
Gene names (primary )：Prph
Gene names (synonym )：Prph1
Gene names (ORF )：
Length：475
Mass：54268
Sequence：MPSSASMSHHHSSGLRSSISSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSGSPSSSARLGSFRAPRAGALRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLSLKTTVPEMEPLQDSHSKKMVLIRTIETRDGEKVVTESQKEQHSDLDKSSIHSY
Tissue specificity：Expressed in the sciatic nerve and at very low levels in the central nervous system (at protein level) (PubMed:22723690). Expressed in the spinal cord, in the sciatic nerve at the level of the dorsal root ganglion and in trigeminal nerves (at protein level) (PubMed:12065660). Expressed in the cranial nerves in the hindbrain, including the sensory and motor trigeminal neurons, the mesencephalic trigeminal neurons, the spinal trigeminal neurons, and in the facial nerve (at protein level) (PubMed:17899157). Expressed in the cerebellum, with expression in the inferior cerebellar peduncle and the lateral deep cerebellar nucleus (at protein level) (PubMed:17899157). Expressed in vestibulocochlear neurons, such as the anteroventral cochlear nucleus, the dorsal cochlear nucleus, the superficial granule cell layer and the granule cell lamina (at protein level) (PubMed:17899157). Expressed in glossopharyngeal, vagal and hypoglossal neurons (at protein level) (PubMed:17899157). Expressed in peripheral sensory neurons, in the dorsal root ganglia and the spinal cord, and to a lower extent in motor neurons (PubMed:18709437). Expressed in the optic tract of the central nervous system, especially in the lateral geniculate nucleus and the superior colliculus (PubMed:18709437). Expressed in neurons of the pineal stalk in the cortex (PubMed:18709437). Expressed in the spinal trigeminal tract of the midbrain, in the medulla and in the medial cerebellar peduncle (PubMed:18709437). {ECO:0000269|PubMed:12065660, ECO:0000269|PubMed:17899157, ECO:0000269|PubMed:18709437, ECO:0000269|PubMed:22723690}.
Induction：
Developmental stage：Expressed in the dorsal root ganglia and in the spinal cord at 9.5 dpc (PubMed:18709437). Expressed in the neurons that innervate the limb buds at 13 dpc (PubMed:18709437). Expressed in the dorsal root ganglia and the sciatic nerve at 13.5 dpc (PubMed:23179371). Expressed in type I and type II spiral ganglion neurons of the cochlea at postnatal days P1 to P7 (PubMed:20132868). {ECO:0000269|PubMed:18709437, ECO:0000269|PubMed:20132868, ECO:0000269|PubMed:23179371}.
Protein families：Intermediate filament family