PHEX_MOUSE P70669
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UniProt:P70669
Recommended name：Phosphate-regulating neutral endopeptidase PHEX
EC number：EC 3.4.24.-
Alternative names：(Metalloendopeptidase homolog PEX) (Phosphate regulating neutral endopeptidase) (Vitamin D-resistant hypophosphatemic rickets protein) (X-linked hypophosphatemia protein) (HYP)
Cleaved into：
GeneID：18675
Gene names (primary )：Phex
Gene names (synonym )：Hyp Pex
Gene names (ORF )：
Length：749
Mass：86419
Sequence：MEAETGSTMETGKGTNRGIRIALALFIGGTLVLGTLLFLVSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSVSRRRDTEAVQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAVLAKVGYPEFIMNDTYVNEDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPRNSTMNRGADSCRLW
Tissue specificity：Expressed in bone, specifically in the osteoid and in osteocytes (PubMed:11159866, PubMed:18597632). Expressed in teeth, specifically in odontoblasts and ameloblasts (PubMed:11811562). Expressed moderately by macrophages in the liver and has minimal expression in brown adipose tissue (PubMed:11811562). Also expressed in suprabasal layers of the skin (PubMed:11811562). {ECO:0000269|PubMed:11159866, ECO:0000269|PubMed:11811562, ECO:0000269|PubMed:18597632}.
Induction：
Developmental stage：Detected at 16 and 18 days post coitum (dpc) in vertebrae osteoblasts. Detected in calvarial tissue and in the stratum spinosum and granulosum of the overlaying epidermis at 18 dpc. Detected at postnatal day 14 in osteoblasts and osteocytes of the calvarium. Detected in tibias at postnatal day 14 in osteoblasts and a lesser degree in osteocytes, however by postnatal day 84 it is detected in osteocytes in compact bone. Detected in teeth at postnatal day 14 in odontoblasts and ameloblasts. By postnatal day 84, expression can still be detected in odontoblasts however little to no expression can be detected in ameloblasts. Detected at 18 dpc at moderate levels in macrophages within the liver, with minimal expression in brown adipose tissue. Detected at 18 dpc in suprabasal layers of the skin. {ECO:0000269|PubMed:11811562}.
Protein families：Peptidase M13 family