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MPO molecular target information overview


  • Molecular name: MPO, myeloperoxidase


    • Overview of MPO molecular targets


    Myeloperoxidase (MPO) is a peroxidase that is encoded in humans by the MPO gene located on chromosome 17. It is a lysosomal protein present in the azurophilic granules of neutrophils and is released into the extracellular space during degranulation. MPO is most abundantly expressed in neutrophils and produces hypohalous acids with antimicrobial activity. MPO has a heme pigment that causes secretions from neutrophils to appear green, like pus. In addition, MPO mediates protein nitrosylation, 3-chlorotyrosine formation, and dityrosine cross-linking. MPO deficiency is a genetic disease that causes immune deficiency. Elevated MPO levels greatly increase the risk of cardiovascular death. It is also believed that MPO plays an important role in the development of atherosclerotic lesions and in causing plaque instability.


    Human MPO molecular target information


    Molecular name: MPO, myeloperoxidase


    Alias:

    • None

    Gene sequence:NCBI_Gene: 4353

    Protein sequence:UniProtKB: P05164


    Human MPO target molecular function (prediction)


    Enables heparin binding activity and peroxidase activity. Involved in low-density lipoprotein particle remodeling. Acts upstream of or within hydrogen peroxide catabolic process. Located in azurophil granule; extracellular space; and nucleoplasm. Implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). (multiple); glomerulonephritis; and lung disease (multiple).


    Mouse Mpo molecular target information


    Molecular name: Mpo, myeloperoxidase


    Alias:

    • None


    Gene sequence:NCBI_Gene: 17523

    Protein sequence:


    Mouse Mpo target molecular function (prediction)


    Enables peroxidase activity. Acts upstream of or within several processes, including hypochlorous acid biosynthetic process; removal of superoxide radicals; and response to fungus. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MPO (myeloperoxidase).


    Rat Mpo molecular target information


    Molecular name: Mpo, myeloperoxidase

    Alias:

    • Mpo_mapped
    • myeloperoxidase (mapped)

    Gene sequence:NCBI_Gene: 303413

    Protein sequence:


    Rat Mpo target molecular function (prediction)


    Enables peroxidase activity. Involved in several processes, including response to food; response to gold nanoparticle; and response to lipopolysaccharide. Located in extracellular space. Used to study acute kidney failure. Biomarker of chronic obstructive pulmonary disease; cystitis; and renovascular hypertension. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MPO (myeloperoxidase).