IL1RL1 Molecular Target Information Overview
Overview of IL1RL1 molecular targets
Oncogenic suppressor 2 (ST2), also known as IL-1R4, is a glycoprotein member of the IL-1 receptor family that promotes Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiomyocytes. It binds to IL-33, a proinflammatory IL-1 family member with both intracellular and extracellular activity. In addition to its role in promoting mast cell and Th2-dependent inflammation, transmembrane ST2 activation can enhance inflammation-related responses and protect the body from atherosclerosis and cardiomyocyte hypertrophy. Serum soluble ST2 expression levels are increased during inflammation, including allergic asthma, sepsis, trauma, dengue fever, and lung disease. Elevated serum ST2 is also affected by multiple aspects of heart failure, including aortic stenosis, congestive cardiomyopathy, and cardiovascular failure and mortality risk.
Human IL1RL1 Molecular Target Information
Molecular name: IL1RL1, interleukin 1 receptor like 1
Alias:
- DER4
- FIT-1
- growth stimulation-expressed
- homolog of mouse growth stimulation-expressed
- IL33R
- interleukin 1 receptor-like 1
- interleukin 1 receptor-related protein
- interleukin-1 receptor-like 1
- MGC32623
- ST2
- ST2L
- ST2V
- T1
Gene sequence:NCBI_Gene: 9173
Protein sequence: UniProtKB: Q01638
Human IL1RL1 target molecular function (prediction)
Predicted to enable interleukin-33 binding activity and interleukin-33 receptor activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in cytosol; focal adhesion; and plasma membrane. Implicated in asthma and coronary artery disease. Biomarker of several diseases, including Human papillomavirus infectious disease; hemolytic-uremic syndrome; lung disease (multiple); paracoccidioidomycosis; and tongue squamous cell carcinoma.
Mouse Il1rl1 molecular target information
Molecular name: Il1rl1, interleukin 1 receptor-like 1
Alternate names:
- DER4
- Fit-1
- Ly84
- lymphocyte antigen 84
- signal transduction protein 2
- signal transduction protein 2, related sequence 1
- ST2
- St2
- St2-rs1
- ST2L
- T1
- T1 gene
- T1/ST2
Gene sequence:NCBI_Gene: 17082
Protein sequence:
Mouse Il1rl1 target molecular function (prediction)
Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in external side of plasma membrane and extracellular matrix. Is expressed in several structures, including immune system; musculoskeletal system; salivary gland; skin; and visual system. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1).
Rat Il1rl1 molecular target information
Molecular name: Il1rl1, interleukin 1 receptor-like 1
Alias:
- Fit-1
- FIT1
- Fos-responsive gene 1
- Interleukin 1 receptor-like 1 (Fos-responsive gene 1)
- interleukin-1 receptor-like 1
- St2
Gene sequence:NCBI_Gene: 25556
Protein sequence:
Rat Il1rl1 target molecular function (prediction)
Predicted to enable interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to peptide; and negative regulation of cell population proliferation. Located in external side of plasma membrane and extracellular space. Biomarker of acute myocardial infarction and bacterial pneumonia. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1).