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CCL18 molecular target information overview


  • Molecular name: CCL18, CC motif chemokine ligand 18
  • Gene family: Chemokine ligands
  • Alias: DC-CK1;
  • Alias:pulmonary and activation-regulated; small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated; chemokine (CC motif) ligand 18 (pulmonary and activation-regulated); chemokine (CC motif) ligand 18


    • CCL18 molecular target review


    Chemokine CC ligand 18 (CCL18), also known as lung and activation-regulated chemokine (PARC), is mainly produced by antigen-presenting cells in the innate immune system, including dendritic cells, monocytes, and macrophages. CCL18 is involved in attracting naive T cells, regulatory T cells, Th2 cells, immunosuppressive and immature dendritic cells, basophils, and naive and effector B cells. Abnormal expression of CCL18 can be observed in many diseases, including breast cancer, autoimmune diseases, and allergies, and it is believed that abnormal expression of CCL18 plays a role in the progression of these diseases.


    Human CCL18 Molecular Target Information


    Molecular name: CCL18, CC motif chemokine ligand 18


    Synonyms:

    • alternative macrophage activation-associated CC chemokine 1
    • AMAC-1
    • AMAC1
    • CC motif chemokine 18
    • CC chemokine ligand 18
    • CC chemokine PARC
    • chemokine (CC motif) ligand 18 (pulmonary and activation-regulated)
    • chemokine (CC), dendritic
    • CKb7
    • DC-CK1
    • DCCK1
    • dendritic cell chemokine 1
    • macrophage inflammatory protein 4
    • MIP-4
    • PARC
    • pulmonary and activation-regulated chemokine
    • SCYA18
    • small inducible cytokine A18
    • small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
    • small-inducible cytokine A18

    Gene sequence:NCBI_Gene: 6362

    Protein sequence:UniProtKB: P55774


    Human CCL18 target molecular function (prediction)


    Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to be active in extracellular space.


    Mouse Ccl3 molecular target information


    Molecular name: Ccl3, chemokine (CC motif) ligand 3


    Alias:

    • AI323804
    • CCL3
    • expressed sequence AI323804
    • G0S19-1
    • LD78alpha
    • macrophage inflammatory protein-1 alpha
    • macrophage inflammatory protein-1alpha
    • MIP-1 alpha
    • MIP-1alpha
    • MIP1-(a)
    • MIP1-alpha
    • Mip1a
    • Scya3
    • small inducible cytokine A3


    Gene sequence:NCBI_Gene: 20302

    Protein sequence:


    Mouse Ccl3 target molecular function (prediction)


    Enables chemokine activity. Involved in several processes, including astrocyte cell migration; macrophage chemotaxis; and positive regulation of macromolecule metabolic process. Located in extracellular space. Is expressed in articular cartilage; cartilage; knee joint; lung;