AEBP1_MOUSE Q640N1
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UniProt:Q640N1
Recommended name：Adipocyte enhancer-binding protein 1
EC number：
Alternative names：(AE-binding protein 1) (Aortic carboxypeptidase-like protein)
Cleaved into：
GeneID：11568
Gene names (primary )：Aebp1
Gene names (synonym )：Aclp
Gene names (ORF )：
Length：1128
Mass：128365
Sequence：MAPVRTASLLCGLLALLTLCPEGNPQTVLTDDEIEEFLEGFLSELETQSPPREDDVEVQPLPEPTQRPRKSKAGGKQRADVEVPPEKNKDKEKKGKKDKGPKATKPLEGSTRPTKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKRPSAGKKFSTVAPLETLDRLLPSPSNPSAQELPQKRDTPFPNAWQGQGEETQVEAKQPRPEPEEETEMPTLDYNDQIEKEDYEDFEYIRRQKQPRPTPSRRRLWPERPEEKTEEPEERKEVEPPLKPLLPPDYGDSYVIPNYDDLDYYFPHPPPQKPDVGQEVDEEKEEMKKPKKEGSSPKEDTEDKWTVEKNKDHKGPRKGEELEEEWAPVEKIKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGANEDDYYDGAWCAEDESQTQWIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFYGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCPVTPVYSYYAQNEVVTTDSLDFRHHSYKDMRQLMKAVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGDHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCQEYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWAAEEKKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIISWMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAEALAAARGEDDDGVSEAQETPDHAIFRWLAISFASAHLTMTEPYRGGCQAQDYTSGMGIVNGAKWNPRSGTFNDFSYLHTNCLELSVYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTSSAKICNVDYDIGATQCNFILARSNWKRIREILAMNGNRPILRVDPSRPMTPQQRRMQQRRLQYRLRMREQMRLRRLNSTAGPATSPTPALMPPPSPTPAITLRPWEVLPTTTAGWEESETETYTEVVTEFETEYGTDLEVEEIEEEEEEEEEEMDTGLTFPLTTVETYTVNFGDF
Tissue specificity：Isoform 1 and isoform 2 are expressed in adipose tissue, brain, heart, kidney, liver, lung, skeletal muscle, small intestine, spleen and testis. Isoform 2 is expressed in macrophages. Expressed in aorta, preadipocytes, adipocyte tissue, brain, heart, liver, lung, skeletal muscle, skin and spleen (at protein level). {ECO:0000269|PubMed:11438679, ECO:0000269|PubMed:11738825, ECO:0000269|PubMed:9624159}.
Induction：By TGF-beta. Expression is also induced by a high fat diet. {ECO:0000269|PubMed:15927179, ECO:0000269|PubMed:16307171}.
Developmental stage：Expressed in the somites and dorsa from 9.5 dpc and in the yolk sac and embryonic vasculature from 10.5 dpc. Expression within the large and small blood vessels increases at 11.5 dpc and 13.5 dpc, with high expression in the vascular smooth muscle at 16.5 dpc. Also expressed later in development in mesenchymal cells in the dermal layer, the developing skeleton, connective tissue and the umbilical ring and vessels. Up-regulated during vascular smooth muscle cell differentiation and down-regulated during adipocyte differentiation and osteoblast differentiation. {ECO:0000269|PubMed:11152475, ECO:0000269|PubMed:11438679, ECO:0000269|PubMed:12072377, ECO:0000269|PubMed:14729459, ECO:0000269|PubMed:15749083, ECO:0000269|PubMed:15927179, ECO:0000269|PubMed:7477299, ECO:0000269|PubMed:8920928, ECO:0000269|PubMed:9624159}.
Protein families：Peptidase M14 family