ACE2_MOUSE Q8R0I0
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UniProt:Q8R0I0
Recommended name：Angiotensin-converting enzyme 2
EC number：EC 3.4.17.23
Alternative names：(ACE-related carboxypeptidase)
Cleaved into：Processed angiotensin-converting enzyme 2
GeneID：70008
Gene names (primary )：Ace2
Gene names (synonym )：
Gene names (ORF )：
Length：805
Mass：92368
Sequence：MSSSSWLLLSLVAVTTAQSLTEENAKTFLNNFNQEAEDLSYQSSLASWNYNTNITEENAQKMSEAAAKWSAFYEEQSKTAQSFSLQEIQTPIIKRQLQALQQSGSSALSADKNKQLNTILNTMSTIYSTGKVCNPKNPQECLLLEPGLDEIMATSTDYNSRLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYNDYGDYWRGDYEAEGADGYNYNRNQLIEDVERTFAEIKPLYEHLHAYVRRKLMDTYPSYISPTGCLPAHLLGDMWGRFWTNLYPLTVPFAQKPNIDVTDAMMNQGWDAERIFQEAEKFFVSVGLPHMTQGFWANSMLTEPADGRKVVCHPTAWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYARQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSDFQEDSETEINFLLKQALTIVGTLPFTYMLEKWRWMVFRGEIPKEQWMKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSNDYSFIRYYTRTIYQFQFQEALCQAAKYNGSLHKCDISNSTEAGQKLLKMLSLGNSEPWTKALENVVGARNMDVKPLLNYFQPLFDWLKEQNRNSFVGWNTEWSPYADQSIKVRISLKSALGANAYEWTNNEMFLFRSSVAYAMRKYFSIIKNQTVPFLEEDVRVSDLKPRVSFYFFVTSPQNVSDVIPRSEVEDAIRMSRGRINDVFGLNDNSLEFLGIHPTLEPPYQPPVTIWLIIFGVVMALVVVGIIILIVTGIKGRKKKNETKREENPYDSMDIGKGESNAGFQNSDDAQTSF
Tissue specificity：Expressed in heart, kidney and forebrain (at protein level). Expressed in the small intestine, with expression in the intestinal brush border (at protein level) (PubMed:19185582, PubMed:22677001). Ubiquitously expressed, with highest levels in ileum, kidney and lung. In lung, expressed on vascular endothelial and airway epithelial cells. Also expressed at high levels in lung secretory club and goblet cells as well as in alveolar type 2 cells (PubMed:32425701). {ECO:0000269|PubMed:12487024, ECO:0000269|PubMed:15949646, ECO:0000269|PubMed:16001071, ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:22677001, ECO:0000269|PubMed:32425701}.
Induction：Down-regulated in lung after acute injury. Exposure to cigarette smoke increases ACE2 expression up to 80% more in lungs (PubMed:32425701). {ECO:0000269|PubMed:16001071, ECO:0000269|PubMed:32425701}.
Developmental stage：
Protein families：Peptidase M2 family