DPPA3_MOUSE   Q8QZY3


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UniProt:Q8QZY3

Recommended name:Developmental pluripotency-associated protein 3

EC number:

Alternative names:(Compaction-associated protein 1) (Primordial germ cell protein 7)

Cleaved into:

GeneID:73708

Gene names  (primary ):Dppa3

Gene names  (synonym ):Cap1p Crg1 Pgc7

Gene names  (ORF ):

Length:150

Mass:17670

Sequence:MEEPSEKVDPMKDPETPQKKDEEDALDDTDVLQPETLVKVMKKLTLNPGVKRSARRRSLRNRIAAVPVENKSEKIRREVQSAFPKRRVRTLLSVLKDPIAKMRRLVRIEQRQKRLEGNEFERDSEPFRCLCTFCHYQRWDPSENAKIGKN

Tissue specificity:Expressed in the immature oocytes and in newborn ovaries. Subsequently detected in maturing oocytes and in preimplantation embryos. Expressed in pluripotent embryonic but not in differentiated somatic cells. Expressed in blastocysts, epiblasts, primordial germ cells, embryonic gonads and primitive spermatogonia. No expression is detected in adult testes. {ECO:0000269|PubMed:11900980, ECO:0000269|PubMed:12124616, ECO:0000269|PubMed:12620990}.

Induction:

Developmental stage:Detected at 3.5 dpc (at protein level). Activated during the process of germ cell specification at 7 dpc.25, specifically in the founder population of lineage-restricted primordial germ cells (PGCs). Thereafter, expressed in the germ line until about 15.5 dpc in male and 13.5 dpc in female gonads. Expressed during blastocyst, morula and 4-cell embryo stages. {ECO:0000269|PubMed:11900980, ECO:0000269|PubMed:12620990, ECO:0000269|PubMed:14654002, ECO:0000269|PubMed:14684992}.

Protein families:


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