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ICAM1 molecular target review

Intercellular adhesion molecule 1 (ICAM-1), also known as CD54, is an almost ubiquitous transmembrane glycoprotein that is normally expressed on endothelial cells and immune cells and plays a key role in leukocyte migration and activation. It binds to CD11a/CD18 or CD11b/CD18 integrins and is also used as a receptor by rhinovirus. Soluble intercellular adhesion molecule 1 (sICAM-1) promotes angiogenesis and can be used as an indicator of endothelial cell activation or damage. It also acts as a transmembrane ICAM-1 inhibitor, mediating activities such as monocyte adhesion to activated endothelial cells and tumor cell sensitivity to NK cell-mediated lysis. Monitoring sICAM-1 expression levels in serum can provide a more detailed perspective on a variety of pathological conditions, such as cardiovascular disease, type II diabetes, organ transplantation disorders, oxidative stress, abdominal fat, hypertension, liver disease, and certain malignancies.

Human ICAM1 Molecular Target Information

Molecular name:ICAM1, intercellular adhesion molecule 1

Alias:

• BB2
• CD54
• cell surface glycoprotein P3.58
• human rhinovirus receptor
• ICAM-1
• intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
• major group rhinovirus receptor
• P3.58

Gene sequence:NCBI_Gene: 3383

Protein sequence:UniProtKB: P05362

Human ICAM1 target molecular function (prediction)

Enables integrin binding activity. Involved in several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; cellular response to amyloid-beta; and negative regulation of apoptotic process. Located in extracellular exosome. Implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetes mellitus (multiple); hematologic cancer (multiple); and lung disease (multiple).

Mouse Icam1 molecular target information

Molecular name:Icam1, intercellular adhesion molecule 1

Alias:

• CD54
• Icam-1
• Ly-47
• lymphocyte antigen 47
• MALA-2
• MGC:6195

Gene sequence:NCBI_Gene: 15894

Protein sequence:

• UniprotKB: P13597
• UniprotKB: Q3TB10
• UniprotKB: Q3TB21
• UniprotKB: Q3THH5
• UniprotKB: Q3U7Q9
• UniprotKB: Q3U7T2
• UniprotKB: Q3U8M7
• UniprotKB: Q3UAU5
• UniprotKB: Q3UDC5
• UniprotKB: Q3UDJ5
• UniprotKB: Q3UE52
• UniprotKB: Q4FK06
• UniprotKB: Q922B3

  
  

  Mouse Icam1 target molecular function (prediction)

  
  

  Predicted to enable integrin binding activity. Acts upstream of or within several processes, including T cell antigen processing and presentation; cellular response to glucose stimulus; and cellular response to leukemia inhibitory factor. Located in external side of plasma membrane and immunological synapse. Colocalizes with membrane raft. Is expressed in several structures, including cardiovascular system; liver vasculature; lung; skin; and thymus primordium. Used to study malaria. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; inflammatory bowel disease (multiple); liver cirrhosis; and uveitis (multiple). Orthologous to human ICAM1 (intercellular adhesion molecule 1).

  
  

  Rat Icam1 molecular target information

  
  

  Molecular name:Icam1, intercellular adhesion molecule 1

  Alias:

  • CD54
  • ICAM
  • ICAM-1

  Gene sequence:NCBI_Gene: 25464

  Protein sequence:UniProtKB: Q00238

  
  

  Rat Icam1 target molecular function (prediction)

  
  

  Enables integrin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and gonad development. Located in cell surface; extracellular space; and plasma membrane. Used to study diabetic angiopathy; mesenteric vascular occlusion; nephritis; pre-eclampsia; lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Orthologous to human ICAM1 (intercellular adhesion molecule 1).