UPP2_MOUSE Q8CGR7
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UniProt:Q8CGR7
Recommended name：Uridine phosphorylase 2
EC number：EC 2.4.2.3
Alternative names：(UPase 2) (UrdPase 2) (Liver-specific uridine phosphorylase) (L-UrdPase)
Cleaved into：
GeneID：76654
Gene names (primary )：Upp2
Gene names (synonym )：
Gene names (ORF )：
Length：320
Mass：35755
Sequence：MASILPASNRSMRPDKNTYERKRSVYVKNPYLEGMDEDILYHLDLGTKTHNLPAMFGDVKFVCVGGSPNRMKAFAQFMHKELRLEGDGEDIEDICAGTDRYCMFKTGPVLSVSHGMGIPSISIMLHELIKLLHHAHCCDVTIIRIGTSGGIGIAPGSVVITDTAVDSFFKPRFEQVILDNVVTRSTELDKELANDLFNCSREIPNVPTLIGHTMCTYDFYEGQGRLDGALCSFSREKKLDYLKRAYRAGVRNIEMESTVFAAMCGLCGLRAAVVCVTLLDRLESDQINLSHDVLVEYQQRPQLLISNFIKKQLGLCDQMS
Tissue specificity：Liver specific. {ECO:0000269|PubMed:14715930}.
Induction：Directly up-regulated in liver by HNF-4-alpha (HNF4A) binding to the promoter. May also be indirectly regulated by signaling via various orphan nuclear receptors. Strongly up-regulated by a liver X receptor (LXR) agonist. Slightly up-regulated by a pregnane X receptor (PXR) agonist. Strongly repressed by a peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Slightly repressed by a farnesoid X receptor (FXR) agonist. Shows a diurnal expression pattern with peak levels 12 hours after light onset and lowest levels 0 hours after light onset. {ECO:0000269|PubMed:14715930}.
Developmental stage：
Protein families：PNP/UDP phosphorylase family