GZMB molecular target information overview

GZMB molecular target information overview


  • Molecular name: GZMB, granzyme B
  • Gene family: Granule associated serine proteases of immune defense
  • Alias: CCPI; CGL-1; CSP-B; CGL1; CTSGL1; HLP; SECT
  • Previous names: CTLA1; CSPB
  • Alias: fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cell serine protease 1-3E; granzyme 2; cytotoxic T-lymphocyte-associated serine esterase 1; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)


    • Overview of GZMB molecular targets


    Granzyme B is a serine protease most commonly found in the granules of cytotoxic lymphocytes (CTLs) and natural killer cells (NK cells). Granzyme B secreted by these cells works together with perforin to mediate apoptosis of target cells. Recently, it has been discovered that many non-cytotoxic cells, from basophils, mast cells to smooth muscle cells, can also produce Granzyme B. Granzyme B participates in inducing inflammation by stimulating the release of cytokines and is also involved in extracellular matrix remodeling. Elevated Granzyme B levels are associated with many autoimmune diseases, some skin diseases, and type 1 diabetes.


    Human GZMB Molecular Target Information


    Molecular name: GZMB, granzyme B


    Alias:

    • C11
    • cathepsin G-like 1
    • CCPI
    • CGL-1
    • CGL1
    • CSP-B
    • CSPB
    • CTLA-1
    • CTLA1
    • CTSGL1
    • cytotoxic serine protease B
    • cytotoxic T-lymphocyte proteinase 2
    • cytotoxic T-lymphocyte-associated serine esterase 1
    • fragmentin 2
    • fragmentin-2
    • granzyme 2
    • granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
    • granzyme-2
    • HLP
    • human lymphocyte protein
    • lymphocyte protease
    • SECT
    • T-cell serine protease 1-3E

    Gene sequence:NCBI_Gene: 3002

    Protein sequence:UniProtKB: P10144


    Human GZMB target molecular function (prediction)


    Enables serine-type endopeptidase activity. Involved in several processes, including granzyme-mediated programmed cell death signaling pathway; natural killer cell mediated cytotoxicity; and pyroptosis. Located in cytolytic granule. Biomarker of COVID-19; bronchiolitis obliterans; and chronic obstructive pulmonary disease.


    Mouse Gzme molecular target information


    Molecular name: Gzme, granzyme E


    Alias:

    • CCP3
    • Ctla-6
    • Ctla6
    • cytotoxic T lymphocyte-associated protein 6
    • MCSP-2


    Gene sequence:NCBI_Gene: 14942

    Protein sequence:


    Mouse Gzme target molecular function (prediction)


    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including granzyme-mediated programmed cell death signaling pathway; natural killer cell mediated cytotoxicity; and pyroptosis. Predicted to act upstream of or within cytolysis. Predicted to be located in cytolytic granule. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. spongiotrophoblast; and trophoblast giant cell. Orthologous to human GZMB (granzyme B).


    Rat Gzmb molecular target information


    Molecular name: Gzmb, granzyme B

    Alias:

    • fragmentin
    • GLP I
    • GLP III
    • GLP-1
    • granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
    • granzyme-like protein 1
    • granzyme-like protein I
    • LOW QUALITY PROTEIN: granzyme-like protein 1
    • MGC156565
    • natural killer cell protease 1
    • RNKP-1

    Gene sequence:NCBI_Gene: 171528

    Protein sequence:


    Rat Gzmb target molecular function (prediction)


    Enables serine-type endopeptidase activity. Involved in positive regulation of necroptotic process. Located in early endosome. Orthologous to human GZMB (granzyme B).

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