PJVK_MOUSE Q0ZLH2
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UniProt:Q0ZLH2
Recommended name：Pejvakin
EC number：
Alternative names：(Protein sirtaki)
Cleaved into：
GeneID：381375
Gene names (primary )：Pjvk
Gene names (synonym )：Dfnb59 Gm1001
Gene names (ORF )：
Length：352
Mass：39858
Sequence：MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRCKFTSTPFTLKDILLGDREISAGISSYQLLNYEDESDVSLYGRRSNHIVNDVGINVTGSDSIAVKASFGVVTKHEVEVSTLLKEITARKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGREKAIVFPAHTTIAFSVFELFIYLDGAFDICVTSVSKGGFEREETTTFAMFYRLRNILFERNRRVMDAISRSQLYLDDLFSDFYDKPLSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNLKRETVYGCFQCSVDGVKYVRLHAVPCFDIWHKRMK
Tissue specificity：In ear, it is detected in the organ of Corti and the spiral ganglion within the cochlea in the sensory areas of the vestibule (cristae ampullares of the semicircular ducts, and maculae of the saccule and utricle) and in the first 3 relays (cochlear nuclei, superior olivary complex and inferior colliculus) of the afferent auditory pathway (PubMed:16804542). Detected in hair cells of the cochlea and vestibule but not in neurons (PubMed:17329413, PubMed:28089576). In the afferent auditory pathway, it is present in the cell bodies of neurons but not in fiber bundles such as the trapezoid body in the brainstem (PubMed:16804542). Also detected in spiral ganglion cells, which form the auditory nerve and project to the cochlear nuclei in the brainstem (PubMed:16804542). Also present in the cochlear nuclei, the superior olive and the inferior colliculus (at protein level) (PubMed:16804542). Expressed in all the adult organs tested: brain, eye, inner ear, heart, lung, kidney, liver, intestine, testis and weakly in skeletal muscle (PubMed:16804542). {ECO:0000269|PubMed:16804542, ECO:0000269|PubMed:17329413, ECO:0000269|PubMed:28089576}.
Induction：By noise exposure. {ECO:0000269|PubMed:26544938}.
Developmental stage：
Protein families：Gasdermin family