T22D3_MOUSE Q9Z2S7
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UniProt:Q9Z2S7
Recommended name：TSC22 domain family protein 3
EC number：
Alternative names：(Glucocorticoid-induced leucine zipper protein) (TSC22-related-inducible leucine zipper 3) (Tilz3)
Cleaved into：
GeneID：14605
Gene names (primary )：Tsc22d3
Gene names (synonym )：Dsip1 Dsipi Gilz
Gene names (ORF )：
Length：137
Mass：15177
Sequence：MNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVVSVKLDNSASGASVVALDNKIEQAMDLVKNHLMYAVREEVEVLKEQIRELLEKNSQLERENTLLKTLASPEQLEKFQSRLSPEEPAPEAPETPETPEAPGGSAV
Tissue specificity：Constitutively expressed in lung, intestine, kidney and liver, most probably by resident cells from the macrophage lineage. Expression inversely correlates with T-cell activation, being higher in resting cells and lower in cells activated by TCR/CD3 triggering. Isoform 1 and isoform 4 are expressed in spleen and skeletal muscle (at protein level). Isoform 1 is expressed in thymus, lymph nodes, bone marrow, spleen, lung and skeletal muscle. {ECO:0000269|PubMed:11468175, ECO:0000269|PubMed:12393603, ECO:0000269|PubMed:20124407}.
Induction：By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells. Isoform 1 and isoform 4 expression is up-regulated by the synthetic glucocorticoid dexamethasone in differentiating myoblasts. {ECO:0000269|PubMed:12393603, ECO:0000269|PubMed:15031210, ECO:0000269|PubMed:20124407, ECO:0000269|PubMed:9430225}.
Developmental stage：Isoform 1 and isoform 4 are expressed in differentiating myoblasts at a time of myotube formation. {ECO:0000269|PubMed:20124407}.
Protein families：TSC-22/Dip/Bun family