RN146_MOUSE Q9CZW6
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UniProt:Q9CZW6
Recommended name：E3 ubiquitin-protein ligase RNF146
EC number：EC 2.3.2.27
Alternative names：(Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)
Cleaved into：
GeneID：68031
Gene names (primary )：Rnf146
Gene names (synonym )：
Gene names (ORF )：
Length：359
Mass：38934
Sequence：MEMAGCGEIDHSINMLPTNKKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDTNTVNLARESSADGADSGSAQTGASVQLAVPSSTRPLTSVDGQLTSPVTPSPDAGISLEDSFAHLQLSGDSIAERSHRGEGEEDHESPSSGRVPDTSVEETESDASSDSEDAPVVVAQHSLTQQRPLVPNGNQTVADQSDRSGTDRSVAGGGTMSVNVRSRRPDGQCTVTEV
Tissue specificity：Expressed at relatively high levels in the brain. Also present in spleen, heart, kidney, testis and liver. In the brain, expressed in the cerebellum, hippocampus, striatum, cortex, frontal cortex and, at lowest levels, in olfactory bulb (at protein level). Predominantly expressed in neurons. {ECO:0000269|PubMed:15813938, ECO:0000269|PubMed:21602803}.
Induction：Up-regulated in cortical neurons by treatment with N-methyl-D-aspartate (NMDA). Toxic doses of NMDA fail to induce Iduna expression. Sublethal exposure to oxygen-glucose deprivation also induces Iduna protein expression. Also induced by treatments that result in resistance to subsequent ischemic injury, such as 5 minute bilateral common carotid artery occlusion (at protein level). {ECO:0000269|PubMed:21602803}.
Developmental stage：
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