UNC5C_MOUSE O08747
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UniProt:O08747
Recommended name：Netrin receptor UNC5C
EC number：
Alternative names：(Protein unc-5 homolog 3) (Protein unc-5 homolog C) (Rostral cerebellar malformation protein)
Cleaved into：
GeneID：22253
Gene names (primary )：Unc5c
Gene names (synonym )：Rcm Unc5h3
Gene names (ORF )：
Length：931
Mass：103063
Sequence：MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDEFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPAEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTSWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQAAPDSDDVALYVGIVIAVTVCLAITVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSSKLSPQMTQSLLENEALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGRVYEMYVTVHRKENMRPPMEDSQTLLTPVVSCGPPGALLTRPVILTLHHCADPSTEDWKIQLKNQAVQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHIWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPASTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY
Tissue specificity：Expressed in cortical and cerebellar neurons, including cells of the external and internal granular layer and of the Purkinje cell layer (at protein level) (PubMed:22685302, PubMed:28483977). Mainly expressed in regions of differentiating neurons (PubMed:9126743). Highly expressed in brain and lung (PubMed:9126743, PubMed:9389662). Expressed in the cerebellum and the neurons of the hippocampus, with enrichment in neurons of the CA3 hippocampal pyramidal layer (PubMed:25419706). Weakly expressed in testis, ovary, spleen, thymus and bladder (PubMed:9126743). Expressed at very low level in kidney, intestine and salivary gland (PubMed:9126743). {ECO:0000269|PubMed:22685302, ECO:0000269|PubMed:25419706, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:9126743, ECO:0000269|PubMed:9389662}.
Induction：
Developmental stage：Detected at 15 dpc in the cortex and cerebellum and at postnatal day 2 and 4 in the cerebellum (at protein level). {ECO:0000269|PubMed:22685302, ECO:0000269|PubMed:28483977}.
Protein families：Unc-5 family