NTRK2 molecular target information overview
Overview of NTRK2 molecular targets
Tropomyosin kinase receptor B (TrkB), also known as tyrosine kinase receptor B, is a receptor for brain-derived neurotrophic factor (BDNF) and a member of the neurotrophin tyrosine kinase receptor (NTRK) family. This kinase is a membrane-bound receptor expressed exclusively in neurons of the central nervous system. TrkB mediates many of the actions of neurotrophins such as BDNF, neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3), including neuronal differentiation and survival. In the extracellular domain, it has two distinct regions that bind BDNF with high affinity. Once bound to neurotrophins, TrkB itself and downstream members of the associated signaling pathways become phosphorylated. TrkB plays an important role in tumorigenesis and metastasis, and mutations in this gene are associated with obesity and mood disorders. Therefore, BDNF/TrkB signaling is considered a potential target for the treatment of schizophrenia.
Human NTRK2 molecular target information
Molecular name: NTRK2, neurotrophic receptor tyrosine kinase 2
Alias:
- BDNF-tropomyosine receptor kinase B
- BDNF/NT-3 growth factors receptor
- DEE58
- EIEE58
- GP145-TrkB
- neurotrophic tyrosine kinase receptor type 2
- neurotrophic tyrosine kinase, receptor, type 2
- neurotrophic tyrosine receptor kinase type 2
- OBHD
- trk-B
- TRKB
- trkB tyrosine kinase
- tropomyosin-related kinase B
- tyrosine kinase receptor B
Gene sequence:NCBI_Gene: 4915
Protein sequence:UniProtKB: Q16620
Human NTRK2 target molecular function (prediction)
Enables brain-derived neurotrophic factor-activated receptor activity; neurotrophin binding activity; and protease binding activity. Involved in brain-derived neurotrophic factor receptor signaling pathway. Acts upstream of or within negative regulation of amyloid-beta formation. Is integral component of plasma membrane. Part of receptor complex. Implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Biomarker of bipolar disorder; idiopathic pulmonary fibrosis; major depressive disorder; and schizophrenia.
Mouse Ntrk2 molecular target information
Molecular name: Ntrk2, neurotrophic tyrosine kinase, receptor, type 2
Alternate names:
- AI848316
- C030027L06Rik
- expressed sequence AI848316
- RIKEN cDNA C030027L06 gene
- Tkrb
- trkB
- tyrosine protein kinase receptor
Gene sequence:NCBI_Gene: 18212
Protein sequence:
- UniprotKB: P15209
- UniprotKB: A0A286YCB7
- UniprotKB: A0A286YCV8
- UniprotKB: A0A286YDA0
- UniprotKB: A0A286YDA3
- UniprotKB: B5BQV3
- UniprotKB: B5BQV4
- UniprotKB: Q3UHE3
- UniprotKB: S5N1F5
- UniprotKB: W8R8Q6
Mouse Ntrk2 target molecular function (prediction)
Enables brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor-activated receptor activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; nervous system development; and trans-synaptic signaling, modulating synaptic transmission. Acts upstream of or within several processes, including neurogenesis; neuronal action potential propagation; endosome; postsynaptic density; and postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; future brain; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).
Rat Ntrk2 molecular target information
Molecular name: Ntrk2, neurotrophic receptor tyrosine kinase 2
Alias:
- BDNF/NT-3 growth factors receptor
- GP145-TrkB/GP95-TrkB
- Neural receptor protein-tyrosine kinase (trkB)
- neurotrophic tyrosine kinase, receptor, type 2
- neurotrophic tyrosine receptor kinase type 2
- RATTRKB1
- Tkrb
- trk-B
- trkB
- trkB tyrosine kinase
- TRKB1
Gene sequence:NCBI_Gene: 25054
Protein sequence:
Rat Ntrk2 target molecular function (prediction)
Acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway. Located in several cellular components, including distal axon; perikaryon; and postsynaptic density. Is integral component of plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study glaucoma. Biomarker of several diseases, including attention deficit hyperactivity disorder; colitis; mental depression; post-traumatic stress disorder; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).