PARP1_MOUSE P11103
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UniProt:P11103
Recommended name：Poly [ADP-ribose] polymerase 1
EC number：EC 2.4.2.30
Alternative names：(PARP-1) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (msPARP) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-)
Cleaved into：
GeneID：
Gene names (primary )：Parp1
Gene names (synonym )：Adprp Adprt Adprt1
Gene names (ORF )：
Length：1013
Mass：113100
Sequence：MAEASERLYRVQYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGQSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVAGKGQDGSGGKAEKTLGDFAAEYAKSNRSMCKGCLEKIEKGQMRLSKKMVDPEKPQLGMIDRWYHPTCFVKKRDELGFRPEYSASQLKGFSLLSAEDKEALKKQLPAIKNEGKRKGDEVDGTDEVAKKKSRKETDKYSKLEKALKAQNELIWNIKDELKKACSTNDLKELLIFNQQQVPSGESAILDRVADGMAFGALLPCKECSGQLVFKSDAYYCTGDVTAWTKCMVKTQNPSRKEWVTPKEFREISYLKKLKVKKQDRIFPPESSAPITVHWPLSVTSAPTAVNSSAPADKPLSNMKILTLGKLSQNKDEAKAVIEKLGGKLTGSANKASLCISIKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQDLLSAHSLSPWGAEVKAEPGEVVAPRGKSAAPSKKSKGCFKEEGVNKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKESRYWIFRSWGRLGTVIGSNKLEQMPSKEEAVEQFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVKPGTKSKLPKPVQELVGMIFDVDSMKKALVEYEIDLQKMPLGKLSRRQIQAAYSILSEVQQPVSQGSSESQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEVIRKYVKNTHATTHNAYDLEVIDIFKIEREGESQRYKPFRQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLIMLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSASITLEGVEVPLGTGIPSGVNDTALLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
Tissue specificity：Widely expressed (PubMed:9642267). Expression is correlated with proliferation, with higher levels occurring during early fetal development and organogenesis and in the highly proliferative cell compartments of adult (PubMed:9642267). Expressed in B-cells that have been induced to switch to various Ig isotypes (PubMed:9642267). {ECO:0000269|PubMed:9642267}.
Induction：
Developmental stage：At stage 12.5 dpc, expressed at high level in the developing liver and kidneys (PubMed:11948190). Expressed at higher level in the genital ridge and the spinal ganglia (PubMed:11948190). At 18.5 dpc, preferentially expressed in the thymus and in regions of the nervous system (PubMed:11948190). Within the developing trunk, preferential expression persisted in the liver and became restricted to the cortical region of the kidney, spleen, adrenal gland, and to stomach and intestinal epithelia (PubMed:11948190). From 14.5 dpc to 18.5 dpc, as well as in the adult, expressed at the highest level in thymus (PubMed:11948190). Expression is particularly high in the subcapsular zone of the thymus where immature lymphocytes proliferate (PubMed:11948190). Expressed at high level in the seminiferous tubules of the developing testis (PubMed:11948190). {ECO:0000269|PubMed:11948190}.
Protein families：